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Rhod-FF AM
| Catalog Number | A14-0100 |
| Category | Calcium, Chloride and Other indicators |
| Molecular Formula | C51H55BrF2N4O19 |
| Molecular Weight | 1145.9 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Rhod-FF AM is a cell-permeant calcium indicator. Rhod-FF AM is hydrolyzed by intracellular esterases to release Rhod-FF upon entering the cell. It is suitable for detection of relatively high level of calcium for its low affinity for calcium.
Chemical Information
Product Specification
Application
| Synonyms | Rhod-FF Acetoxymethyl ester |
| Appearance | Solid Powder |
| Excitation | 556 |
| Emission | 578 ±5 |
Rhod-FF AM, a widely utilized fluorescent calcium indicator, finds various applications in bioscience. Here are four key applications of Rhod-FF AM:
Live-Cell Imaging: Embracing real-time dynamics, Rhod-FF AM serves as a pivotal tool for live-cell imaging, enabling researchers to track intracellular calcium fluctuations. By introducing this indicator into cells, scientists can witness the ebb and flow of calcium linked to diverse cellular processes. This critical application sheds light on signaling pathways and cellular responses, shaping our comprehension of health and disease at a microscopic level.
Neuroscience Research: In the intricate realm of neuroscience, Rhod-FF AM emerges as a crucial ally for unraveling the mysteries of calcium signaling within neurons and glial cells. Delving into areas like neuronal activity, synaptic transmission, and neuroplasticity, this indicator provides intricate details on calcium-mediated processes. By peering into these realms, researchers glean profound insights into brain function, paving the way for novel treatments targeting neurological disorders.
Drug Screening: Stepping into the realm of high-throughput drug screening, Rhod-FF AM takes center stage in evaluating the impact of compounds on cellular calcium levels. Through the nuanced measurement of fluorescence fluctuations, researchers unearth potential drug candidates capable of modulating calcium signaling pathways. This application plays a pivotal role in unearthing novel therapeutic agents across a spectrum of diseases, driving forward the frontiers of pharmaceutical discovery.
Cardiovascular Research: Enriching cardiovascular studies, Rhod-FF AM contributes significantly to the exploration of calcium dynamics within cardiomyocytes and vascular smooth muscle cells. By shedding light on the mechanisms underlying cardiac excitation-contraction coupling and vascular tone regulation, this application deepens our understanding of heart function. These insights are crucial for formulating interventions aimed at combating cardiovascular diseases and advancing cardiac care.
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