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N-(Propargyl-PEG2)-N-bis(PEG3-t-butyl ester)
| Catalog Number | R01-0089 |
| Category | Alkynes |
| Molecular Formula | C33H61NO12 |
| Molecular Weight | 663.9 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
N-(Propargyl-PEG2)-N-bis(PEG3-t-butyl ester) is a 3-arm PEG reagent with a propargyl groups and two t-butyl ester groups. The propargyl group can react with azides via copper catalyzed Click Chemistry reaction to yield a stable triazole linkage. The t-butyl ester groups can be deprotected under acidic conditions.
Chemical Information
Product Specification
Application
Computed Properties
| Purity | 98% |
| IUPAC Name | tert-butyl 3-[2-[2-[2-[2-[2-[2-[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]ethoxy]ethoxy]ethyl-[2-(2-prop-2-ynoxyethoxy)ethyl]amino]ethoxy]ethoxy]ethoxy]propanoate |
| Canonical SMILES | CC(C)(C)OC(=O)CCOCCOCCOCCN(CCOCCOCCOCCC(=O)OC(C)(C)C)CCOCCOCC#C |
| InChI | InChI=1S/C33H61NO12/c1-8-14-37-20-23-40-17-11-34(12-18-41-24-28-43-26-21-38-15-9-30(35)45-32(2,3)4)13-19-42-25-29-44-27-22-39-16-10-31(36)46-33(5,6)7/h1H,9-29H2,2-7H3 |
| InChIKey | UMOGPHKYWRLHFJ-UHFFFAOYSA-N |
| Storage | -20 °C |
N-(Propargyl-PEG2)-N-bis(PEG3-t-butyl ester) is a highly versatile chemical compound commonly employed in biochemical and pharmaceutical research. Here are four key applications:
Conjugation Chemistry: Acting as a pivotal linker in bioconjugation processes, this compound facilitates the coupling of various biomolecules. By enabling the attachment of drugs, proteins, or other ligands to diverse carriers, it enhances their stability and functionality. This critical application plays a key role in shaping targeted drug delivery systems and cutting-edge diagnostic tools.
Drug Delivery Systems: At the forefront of pharmaceutical innovation, N-(Propargyl-PEG2)-N-bis(PEG3-t-butyl ester) is instrumental in crafting advanced drug delivery platforms. Leveraging its PEGylation ability, it enhances the solubility and biocompatibility of therapeutic agents, thereby optimizing the pharmacokinetic profiles of drugs. This results in elevated efficacy and minimized side effects.
Polymer Science: Within the realm of polymer chemistry, this compound serves as a fundamental component in synthesizing functionalized polymers and dendrimers. Serving as a cornerstone in the development of novel polymeric materials with tailored properties, these materials find applications in various domains, including biomedical devices, coatings, and nano-carriers.
Proteomics and Molecular Biology: Delving into the intricate world of proteomics, N-(Propargyl-PEG2)-N-bis(PEG3-t-butyl ester) plays a vital role in unraveling protein interactions and modifications. By integrating into labeling strategies to tag specific proteins, it enables their visualization and analysis through a range of detection methods. This indispensable tool is essential for deciphering protein functionality and pinpointing potential biomarkers, offering profound insights into the molecular landscape.
| XLogP3 | 0.8 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 13 |
| Rotatable Bond Count | 35 |
| Exact Mass | 663.41937638 g/mol |
| Monoisotopic Mass | 663.41937638 g/mol |
| Topological Polar Surface Area | 130Ų |
| Heavy Atom Count | 46 |
| Formal Charge | 0 |
| Complexity | 738 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
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