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Fluorescein | 2321-07-5
| Catalog Number | F04-0037 |
| Category | Fluorescein FAM |
| Molecular Formula | C20H12O5 |
| Molecular Weight | 332.31 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| F04-0037 | -- | $-- |
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Product Introduction
Fluorescein is a synthetic fluorescent tracer, used in ophthalmology as a tool in the diagnosis of corneal abrasions, corneal ulcers and herpetic corneal infections.
Chemical Information |
|
|---|---|
| Related CAS | 518-47-8 (disodium salt) |
| Synonyms | 3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one; C.I. 45350; Colircusi Fluoresceina; D and C Yellow No. 7; D and C Yellow No. 8; Diofluor; Dipotassium Salt, Fluorescein; Disodium Fluorescein; Disodium Salt, Fluorescein; Fluor I Strip A.T.; Fluor-I-Strip A.T.; Fluorescéine sodique Faure; Fluorescein; Fluorescein Dipotassium Salt; Fluorescein Disodium Salt; Fluorescein Monosodium Salt; Fluorescein Sodium; Fluorescein Sodium, Minims; Fluorescein, Disodium; Fluorescein, Sodium; Fluoresceina, Colircusi; Fluoresceine, Minims; Fluorescite; Fluorets; Ful Glo; Ful-Glo; Funduscein; Minims Fluorescein Sodium; Minims Fluoresceine; Minims Stains; Monosodium Salt, Fluorescein; Optifluor Diba; Sodium Fluorescein; Sodium, Fluorescein; Uranine |
| Purity | ≥90% |
| IUPAC Name | 3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one |
| Canonical SMILES | C1=CC=C2C(=C1)C(=O)OC23C4=C(C=C(C=C4)O)OC5=C3C=CC(=C5)O |
| InChI | 1S/C20H12O5/c21-11-5-7-15-17(9-11)24-18-10-12(22)6-8-16(18)20(15)14-4-2-1-3-13(14)19(23)25-20/h1-10,21-22H |
| InChI Key | GNBHRKFJIUUOQI-UHFFFAOYSA-N |
| Solubility | Soluble in DMSO (Slightly), Methanol (Slightly) |
| Density | 1.60±0.1 g/cm3 |
| Appearance | Brown to Dark Red Solid |
| Refractive Index | 1.46355 |
| Boiling Point | 620.8±55.0 °C at 760 Torr |
| Melting Point | 315 °C (decomp) |
| MDL Number | MFCD00005050 |
| Vapor Pressure | 4.1X10-14 mm Hg at 25 °C (est) |
| LogP | 3.4 |
- Product Specification
| Maximum Absorption Wavelength | 490(0.1mol/L NaOH sol.) nm |
| Storage | Store at 2-8°C |
| Signal | Warning |
| GHS Hazard Statements | H302 (13.82%): Harmful if swallowed [Warning Acute toxicity, oral] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] |
| Precautionary Statement Codes | P264, P264+P265, P270, P280, P301+P317, P305+P351+P338, P330, P337+P317, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.) |
Computed Properties | |
|---|---|
| XLogP3 | 3.4 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 0 |
| Exact Mass | 332.06847348 g/mol |
| Monoisotopic Mass | 332.06847348 g/mol |
| Topological Polar Surface Area | 76Ų |
| Heavy Atom Count | 25 |
| Formal Charge | 0 |
| Complexity | 522 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 36870414 | 2023-04-01 | Comparison of adjuvant mechanisms of medium-chain triacylglycerol in a mouse FITC-induced contact hypersensitivity model | Toxicology |
| 28551711 | 2017-12-01 | Why are most phospholipidosis inducers also hERG blockers? | Archives of toxicology |
| 28887287 | 2017-12-01 | Characterization of simvastatin acid uptake by organic anion transporting polypeptide 3A1 (OATP3A1) and influence of drug-drug interaction | Toxicology in vitro : an international journal published in association with BIBRA |
| 28729014 | 2017-11-01 | Evaluating ureteral patency in the post-indigo carmine era: a randomized controlled trial | American journal of obstetrics and gynecology |
| 27989701 | 2017-04-01 | Inhibition of SLC drug transporter activities by environmental bisphenols | Toxicology in vitro : an international journal published in association with BIBRA |
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| WO-2022078524-A2 | Specific conjugation of an antibody | 2021-11-03 |
| WO-2022078524-A4 | Specific conjugation of an antibody | 2021-11-03 |
| US-11331322-B1 | Medicament for preventing and/or treating dry eye | 2021-09-15 |
| US-11535900-B1 | Methods and systems for analysis of samples containing particles used for gene delivery | 2021-09-03 |
| US-2022411856-A1 | Compact optical high-speed system for nucleic acid amplification and detection | 2021-06-29 |
Applications of Fluorescent Probes & Dyes
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