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DBCO-Maleimide | CAS 1395786-30-7
| Catalog Number | R01-0280 |
| Category | Cycloalkyne Dyes (DBCO) |
| Molecular Formula | C25H21N3O4 |
| Molecular Weight | 427.45 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
DBCO-Maleimide is a heterobifunctional ADC linker combining maleimide thiol reactivity and DBCO for copper-free click chemistry, facilitating versatile and site-specific antibody conjugation.
Chemical Information
Product Specification
Computed Properties
Patents
| Synonyms | DBCO-Mal;Dibenzocyclooctyne-maleimide; Azadibenzocyclooctyne-maleimide |
| Purity | >98.0%(HPLC) |
| Shelf Life | 0-4°C for short term (days to weeks), or -20°C for long term (months). |
| IUPAC Name | |
| Canonical SMILES | C1C2=CC=CC=C2C#CC3=CC=CC=C3N1C(=O)CCNC(=O)CCN4C(=O)C=CC4=O |
| InChI | InChI=1S/C25H21N3O4/c29-22(14-16-27-23(30)11-12-24(27)31)26-15-13-25(32)28-17-20-7-2-1-5-18(20)9-10-19-6-3-4-8-21(19)28/h1-8,11-12H,13-17H2,(H,26,29) |
| InChIKey | NHFQNAGPXIVKND-UHFFFAOYSA-N |
| Solubility | 10 mm in DMSO |
| Density | 1.4±0.1 g/cm3 |
| Appearance | White to orange to green powder to crystaline |
| Boiling Point | 790.5±60.0 °C at 760 mmHg |
| Melting Point | 159.0 to 164.0 °C |
| Vapor Pressure | 0.0±2.8 mmHg at 25°C |
| LogP | 3.10 |
| Storage | Keep in freezer under -20°C upon receipt of the product. |
| XLogP3 | 1.3 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 6 |
| Exact Mass | 427.15320616 g/mol |
| Monoisotopic Mass | 427.15320616 g/mol |
| Topological Polar Surface Area | 86.8Ų |
| Heavy Atom Count | 32 |
| Formal Charge | 0 |
| Complexity | 849 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-114504654-A | A kind of platelet preparation for drug delivery and preparation and detection method thereof | 2022-02-10 |
| WO-2023277144-A1 | Humanized antibody capable of binding to heg1 protein, and complex of said antibody and radioactive nuclear species | 2021-06-30 |
| WO-2022265493-A1 | Conjugate of saponin, oligonucleotide and galnac | 2021-06-18 |
| WO-2022263944-A1 | Azido-containing monomers, polymers, and articles | 2021-06-16 |
| WO-2022203082-A1 | Compound, method for producing and method for storing compound, method for producing targeting agent, and composition | 2021-03-26 |
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