Mal-Sulfo-DBCO | CAS 2028281-86-7

Name: Mal-Sulfo-DBCO
Brand: BOC Sciences
Rating: 5 (1 reviews)

Catalog Number	R01-0392
Category	Cycloalkyne Dyes (DBCO)
Molecular Formula	C28H26N4O8S
Molecular Weight	578.59

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Product Introduction

Chemical Information
Product Specification
Application

Synonyms	Sulfo DBCO-Maleimide
Purity	>98.0%
Shelf Life	0-4°C for short term (days to weeks), or -20°C for long term (months).
IUPAC Name
Canonical SMILES	C1C2=CC=CC=C2C#CC3=CC=CC=C3N1C(=O)CCNC(=O)C(CNC(=O)CCN4C(=O)C=CC4=O)S(=O)(=O)O
InChI	InChI=1S/C28H26N4O8S/c33-24(14-16-31-25(34)11-12-26(31)35)30-17-23(41(38,39)40)28(37)29-15-13-27(36)32-18-21-7-2-1-5-19(21)9-10-20-6-3-4-8-22(20)32/h1-8,11-12,23H,13-18H2,(H,29,37)(H,30,33)(H,38,39,40)
InChIKey	IQQMMWCHYXQNOT-UHFFFAOYSA-N
Solubility	10 mm in DMSO
Appearance	Solid

Storage

Store at -20 °C, keep in dry and avoid sunlight.

Mal-Sulfo-DBCO is a bifunctional chemical reagent used in bioconjugation processes, allowing for the covalent linking of molecules in various biological and chemical applications. Here are some key applications of Mal-Sulfo-DBCO:

Protein Labeling: Mal-Sulfo-DBCO can be used to label proteins with fluorescent dyes, enabling visualization and tracking in cellular and molecular studies. By conjugating Mal-Sulfo-DBCO to antibodies or other proteins, researchers can observe their interactions and localizations in different cellular compartments. This is crucial for studying protein dynamics and cellular function.

Drug Delivery Systems: Mal-Sulfo-DBCO is instrumental in developing targeted drug delivery systems by facilitating the conjugation of therapeutic agents to targeting molecules. Drugs can be linked to antibodies or peptides that specifically bind to cancer cells or other disease-specific markers. This enhances the precision and efficacy of treatments, reducing side effects on healthy tissues.

Biomolecule Immobilization: In the creation of biosensors and diagnostic tools, Mal-Sulfo-DBCO is used to immobilize biomolecules onto surfaces. By covalently attaching enzymes, antibodies, or DNA onto sensor surfaces, high sensitivity and specificity in detecting analytes are achieved. This application is vital for the development of point-of-care diagnostics and bioanalytical devices.

Click Chemistry Reactions: Mal-Sulfo-DBCO is employed in click chemistry, a bioorthogonal reaction that allows for efficient and selective conjugation under mild conditions. This reagent reacts with azide-functionalized molecules, enabling the formation of stable bioconjugates without interfering with other biological processes. This technique is highly useful in fabricating complex biomolecular assemblies and studying interactions in living systems.