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Amino-bis-PEG3-DBCO
| Catalog Number | R01-0297 |
| Category | Cycloalkyne Dyes (DBCO) |
| Molecular Formula | C63H79N7O14 |
| Molecular Weight | 1158.34 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| R01-0297 | -- | -- |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Amino-bis-PEG3-DBCO is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Chemical Information
Product Specification
Application
Computed Properties
| Synonyms | Amino-bis-PEG3-DBCO; HY-130972; CS-0119315 |
| Purity | >98.0% |
| Shelf Life | 0-4°C for short term (days to weeks), or -20°C for long term (months). |
| IUPAC Name | N-[2-[2-[2-[2-[3-[2-amino-3-[3-[2-[2-[2-[2-[[4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanoyl]amino]ethoxy]ethoxy]ethoxy]ethylamino]-3-oxopropoxy]propoxy]propanoylamino]ethoxy]ethoxy]ethoxy]ethyl]-4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanamide |
| Canonical SMILES | C1C2=CC=CC=C2C#CC3=CC=CC=C3N1C(=O)CCC(=O)NCCOCCOCCOCCNC(=O)CCOCC(COCCC(=O)NCCOCCOCCOCCNC(=O)CCC(=O)N4CC5=CC=CC=C5C#CC6=CC=CC=C64)N |
| InChI | InChI=1S/C63H79N7O14/c64-55(47-83-31-25-60(73)67-29-35-79-39-43-81-41-37-77-33-27-65-58(71)21-23-62(75)69-45-53-13-3-1-9-49(53)17-19-51-11-5-7-15-56(51)69)48-84-32-26-61(74)68-30-36-80-40-44-82-42-38-78-34-28-66-59(72)22-24-63(76)70-46-54-14-4-2-10-50(54)18-20-52-12-6-8-16-57(52)70/h1-16,55H,21-48,64H2,(H,65,71)(H,66,72)(H,67,73)(H,68,74) |
| InChIKey | IBHGLHHSWOQJHM-UHFFFAOYSA-N |
| Solubility | 10 mm in DMSO |
| Appearance | Light yellow oil |
| Storage | Store at -20 °C, keep in dry and avoid sunlight. |
Amino-bis-PEG3-DBCO, a versatile compound utilized in bioconjugation and chemical biology contexts, offers a wide array of applications. Here are four key applications:
Bioconjugation: Widely employed in bioconjugation processes, Amino-bis-PEG3-DBCO serves as a crucial component for attaching biomolecules to surfaces or other molecules through the mechanism of click chemistry. Its DBCO moiety exhibits rapid reactivity with azide groups, yielding stable triazole linkages without the need for a catalyst. This feature facilitates the creation of diverse bioconjugates tailored for diagnostic, therapeutic, and research applications.
Drug Delivery Systems: Positioned at the forefront of targeted drug delivery innovations, Amino-bis-PEG3-DBCO plays a pivotal role in enabling precise drug delivery systems. By facilitating the conjugation of drugs to targeting ligands through click chemistry, this compound enables the accurate delivery of therapeutic agents to specific cells or tissues, thereby enhancing treatment efficacy while minimizing potential side effects.
Fluorescent Labeling: Researchers leverage Amino-bis-PEG3-DBCO for the fluorescent labeling of biomolecules, a technique crucial for visualizing and tracking proteins, nucleic acids, and other biomolecules within live cells and tissue samples. Through conjugation with fluorescent dyes, this compound enables valuable applications in various imaging and microscopy contexts, offering insights into cellular processes with exquisite detail and precision.
Surface Functionalization: Employed for surface functionalization purposes, Amino-bis-PEG3-DBCO enhances the biocompatibility and specificity of biosensors and biochips by attaching biomolecules like peptides, antibodies, or recognition elements. This augmentation leads to heightened sensitivity and selectivity in analytical devices, broadening the scope of applications across diagnostics, environmental monitoring, and biosensing technologies, thereby advancing the field of chemical biology.
| XLogP3 | 0.3 |
| Hydrogen Bond Donor Count | 5 |
| Hydrogen Bond Acceptor Count | 15 |
| Rotatable Bond Count | 40 |
| Exact Mass | 1157.56850022 g/mol |
| Monoisotopic Mass | 1157.56850022 g/mol |
| Topological Polar Surface Area | 257Ų |
| Heavy Atom Count | 84 |
| Formal Charge | 0 |
| Complexity | 1970 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
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