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DBCO-C6-acid | CAS 1425485-72-8
| Catalog Number | R01-0311 |
| Category | Cycloalkyne Dyes (DBCO) |
| Molecular Formula | C21H19NO3 |
| Molecular Weight | 333.39 |
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Product Introduction
Chemical Information
Product Specification
Application
QC Data
Computed Properties
Patents
| Synonyms | Azadibenzocyclooctyne acid; 6-(11,12-Didehydro-5,6-dihydrodibenzo[b,f]azocine-5-yl)-6-oxohexanoic acid |
| Purity | >95.0% |
| Shelf Life | 0-4°C for short term (days to weeks), or -20°C for long term (months). |
| IUPAC Name | |
| Canonical SMILES | C1C2=CC=CC=C2C#CC3=CC=CC=C3N1C(=O)CCCCC(=O)O |
| InChI | InChI=1S/C21H19NO3/c23-20(11-5-6-12-21(24)25)22-15-18-9-2-1-7-16(18)13-14-17-8-3-4-10-19(17)22/h1-4,7-10H,5-6,11-12,15H2,(H,24,25) |
| InChIKey | NIRLBCOFKPVQLM-UHFFFAOYSA-N |
| Solubility | 10 mm in DMSO |
| Density | 1.3±0.1 g/cm3 |
| Appearance | white to slight grey solid |
| Boiling Point | 634.4±55.0 °C at 760 mmHg |
| Vapor Pressure | 0.0±2.0 mmHg at 25°C |
| LogP | 4.48 |
| Storage | Store at -20 °C, keep in dry and avoid sunlight. |
DBCO-C6-acid, a chemical compound prevalent in bioorthogonal chemistry and molecular imaging, boasts diverse applications in the scientific realm. Here, we delve into four key applications of DBCO-C6-acid:
Bioconjugation: Within bioconjugation techniques, DBCO-C6-acid emerges as a pivotal player, facilitating the attachment of biomolecules like proteins, peptides, or nucleic acids to various substrates. Leveraging the specific reactivity between DBCO and azide groups, researchers can forge stable and precise bioconjugates. This application serves as a linchpin in devising targeted drug delivery systems and diagnostic tools.
Molecular Imaging: In the realm of molecular imaging, DBCO-C6-acid finds utility in labeling biomolecules with imaging agents, enhancing the visualization of intricate biological processes. The DBCO moiety streamlines the conjugation of fluorescent dyes or radioactive isotopes to molecules of interest, enabling real-time monitoring of biological phenomena in vivo.
Cell Surface Engineering: A key player in cell surface engineering, DBCO-C6-acid transforms the landscape of living cell modification by imparting functional moieties onto cellular surfaces. By introducing azide-labeled molecules to cell surfaces, DBCO-C6-acid enables the subsequent attachment of diverse probes and ligands.
Click Chemistry: DBCO-C6-acid stands as an indispensable reagent in the realm of click chemistry, a potent and efficient chemical reaction utilized across various research domains. Through the strain-promoted azide-alkyne cycloaddition (SPAAC) reaction between DBCO and azides, researchers achieve rapid and bioorthogonal formation of covalent bonds. This application finds widespread use in synthesizing complex biomolecules, advancing drug development, and pushing the boundaries of materials science, underscoring its pivotal role in scientific innovation.
| XLogP3 | 3 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 5 |
| Exact Mass | 333.13649347 g/mol |
| Monoisotopic Mass | 333.13649347 g/mol |
| Topological Polar Surface Area | 57.6Ų |
| Heavy Atom Count | 25 |
| Formal Charge | 0 |
| Complexity | 558 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
| Publication Number | Title | Priority Date |
|---|---|---|
| WO-2022225006-A1 | HUMANISED ANTIBODIES LABELLED WITH RADIONUCLIDES THAT EMIT β-RAYS | 2021-04-21 |
| WO-2022224980-A1 | Radioactive complex of anti-cd20 antibody, and radiopharmaceutical | 2021-04-20 |
| WO-2022211051-A1 | Radioactive complex of anti-egfr antibody, and radiopharmaceutical | 2021-03-31 |
| WO-2022203082-A1 | Compound, method for producing and method for storing compound, method for producing targeting agent, and composition | 2021-03-26 |
| WO-2022149578-A1 | Production method for ac-225 solution and production method for medicine using ac-225 solution | 2021-01-08 |
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