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DBCO-PEG4-NHS ester | CAS 1427004-19-0
| Catalog Number | R01-0430 |
| Category | Cycloalkyne Dyes (DBCO) |
| Molecular Formula | C34H39N3O10 |
| Molecular Weight | 649.69 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| R01-0430 | 100 mg | $838 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
DBCO-PEG4-NHS ester is PEG derivative used as a cross-linker to react with primary amines.
Chemical Information
Product Specification
Application
Computed Properties
Patents
| Synonyms | Azadibenzocyclooctyne-PEG4-NHS ester |
| Purity | >95% |
| IUPAC Name | (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[[4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanoyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]propanoate |
| Canonical SMILES | C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCNC(=O)CCC(=O)N2CC3=CC=CC=C3C#CC4=CC=CC=C42 |
| InChI | InChI=1S/C34H39N3O10/c38-30(11-12-31(39)36-25-28-7-2-1-5-26(28)9-10-27-6-3-4-8-29(27)36)35-16-18-44-20-22-46-24-23-45-21-19-43-17-15-34(42)47-37-32(40)13-14-33(37)41/h1-8H,11-25H2,(H,35,38) |
| InChIKey | RRCXYKNJTKJNTD-UHFFFAOYSA-N |
| Solubility | In DMSO: 83.33 mg/mL (128.26 mM; Need ultrasonic) |
| Density | 1.3±0.1 g/cm3 |
| Appearance | Transparent Liquid |
| Storage | 4°C, stored under nitrogen; In solvent, -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
DBCO-PEG4-NHS ester, a versatile bifunctional reagent, plays a significant role in bioconjugation and chemical biology. Here are four key applications of DBCO-PEG4-NHS ester:
Protein Labeling: Utilizing DBCO-PEG4-NHS ester, researchers can intricately label proteins with fluorescent dyes or other reporter molecules. By reacting with primary amines on proteins, it facilitates precise and enduring conjugation. This methodology is indispensable for investigating protein localization, interactions, and dynamics via advanced imaging techniques.
Drug Delivery Systems: The DBCO group within DBCO-PEG4-NHS ester offers a unique avenue for linking drugs or therapeutic agents using click chemistry. This innovative approach can optimize the targeted delivery and controlled release of drugs. Additionally, the PEG spacer imparts solubility and biocompatibility, rendering it suitable for a diverse array of drug delivery applications with increased efficacy.
Surface Functionalization: Widely employed in bioengineering, DBCO-PEG4-NHS ester enables the functionalization of nanoparticle and biomaterial surfaces. This functionality allows for the attachment of key biomolecules like antibodies or ligands to create biofunctional surfaces essential for biosensor development, cell culture optimization, and diagnostic advancements.
Immunoassays: For immunoassay development, DBCO-PEG4-NHS ester emerges as a pivotal tool for conjugating antigens or antibodies to solid supports or detection probes. This process facilitates the precise capture and detection of target molecules, culminating in the creation of vital assays critical in clinical diagnostics, cutting-edge research, and therapeutic monitoring protocols.
| XLogP3 | 0.4 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 10 |
| Rotatable Bond Count | 20 |
| Exact Mass | 649.26354445 g/mol |
| Monoisotopic Mass | 649.26354445 g/mol |
| Topological Polar Surface Area | 150Ų |
| Heavy Atom Count | 47 |
| Formal Charge | 0 |
| Complexity | 1120 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-114231598-A | Homogeneous phase analysis method for visually detecting multiple targets based on click reaction signal amplification and matched equipment thereof | 2021-11-08 |
| CN-114384240-A | Multi-target object simultaneous detection method based on latex microsphere ultraviolet absorption spectrum peak area integral | 2021-11-08 |
| WO-2022221693-A1 | Aluminosilicate nanoparticle sensors and uses thereof | 2021-04-15 |
| WO-2022191679-A1 | Target analyte detection method based on proximity proteolysis reaction | 2021-03-12 |
| WO-2022192674-A1 | Targeted therapeutic lipid nanoparticles and methods of use | 2021-03-11 |
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