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Coumarin 7 | 27425-55-4
| Catalog Number | A17-0067 |
| Category | Laser Dyes |
| Molecular Formula | C20H19N3O2 |
| Molecular Weight | 333.39 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A17-0067 | -- | $-- |
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Product Introduction
Coumarin 7 is an extensively employed synthetic compound within the biomedical sector. It stands as an indispensable fluorescent probe instrumental in scrutinizing multifarious biological mechanisms encompassing the domains of pharmaceutical conveyance, enzymatic operations, and cellular visualization. Furthermore, its profound antioxidant and anti-inflammatory attributes have been recognized, thus unveiling promising therapeutic capabilities towards maladies like cancer and neurodegenerative ailments.
Chemical Information |
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|---|---|
| Synonyms | 3-(1H-benzimidazol-2-yl)-7-(diethylamino)-2H-1-benzopyran-2-one; Coumarin 535; 3-(2-Benzimidazolyl)-7-(diethylamino)coumarin |
| Purity | >98.0%(T)(HPLC) |
| IUPAC Name | 3-(1H-benzimidazol-2-yl)-7-(diethylamino)chromen-2-one |
| Canonical SMILES | CCN(CC)C1=CC2=C(C=C1)C=C(C(=O)O2)C3=NC4=CC=CC=C4N3 |
| InChI | InChI=1S/C20H19N3O2/c1-3-23(4-2)14-10-9-13-11-15(20(24)25-18(13)12-14)19-21-16-7-5-6-8-17(16)22-19/h5-12H,3-4H2,1-2H3,(H,21,22) |
| InChI Key | GOLORTLGFDVFDW-UHFFFAOYSA-N |
| Appearance | White to Light yellow powder to crystal |
| Melting Point | 242 °C |
- Product Specification
- Application
| Storage | Store under inert gas |
| Signal | Warning |
| GHS Hazard Statements | H315 (21.91%): Causes skin irritation [Warning Skin corrosion/irritation] H317 (78.09%): May cause an allergic skin reaction [Warning Sensitization, Skin] H319 (21.91%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (42.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] |
| Precautionary Statement Codes | P261, P264, P264+P265, P271, P272, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P333+P313, P337+P317, P362+P364, P403+P233, P405, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.) |
Coumarin 7, a versatile chemical compound, finds widespread applications in both biomedical and industrial domains. Here are four key applications of Coumarin 7:
Fluorescent Probes: Within biochemical assays and cellular imaging, Coumarin 7 emerges as a remarkable fluorescent probe, enabling real-time tracking of molecular interactions and cellular dynamics. Its luminous properties serve as a vital tool in visualizing and quantifying intricate biological processes, playing a pivotal role in advancing both fundamental research and clinical diagnostics.
Pharmaceuticals: Embracing its role in pharmacology, Coumarin 7 stands as a foundational compound for the development of anticoagulant medications. Its adaptable structure allows for modifications that amplify efficacy while minimizing adverse effects, positioning it as a valuable scaffold for pioneering drug formulations aimed at combating and preventing clot-related disorders.
Cosmetics: Delving into the realm of cosmetics, Coumarin 7 contributes its enticing fragrance and skin-nurturing attributes to an array of beauty products. From perfumes to lotions, this compound adds both functional benefits and aromatic pleasures, catering to consumer preferences for eco-conscious and sustainable beauty solutions, aligning with the shifting landscape of the industry.
Analytical Chemistry: Embracing its analytical prowess, Coumarin 7 emerges as a key reagent in the realm of analytical chemistry, facilitating the detection and quantification of diverse substances with precision and sensitivity. Its application in chromatography and spectrophotometry serves as a cornerstone for quality control in industries like pharmaceuticals and food production, where exact measurements play a crucial role in ensuring product integrity.
Computed Properties | |
|---|---|
| XLogP3 | 4 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 4 |
| Exact Mass | 333.147726857 g/mol |
| Monoisotopic Mass | 333.147726857 g/mol |
| Topological Polar Surface Area | 58.2Ų |
| Heavy Atom Count | 25 |
| Formal Charge | 0 |
| Complexity | 531 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 21992548 | 2012-02-01 | Solanum tuberosum lectin-conjugated PLGA nanoparticles for nose-to-brain delivery: in vivo and in vitro evaluations | Journal of drug targeting |
| 22382327 | 2012-01-01 | Functional characterization of allelic variants of polymorphic human cytochrome P450 2A6 (CYP2A6*5, *7, *8, *18, *19, and *35) | Biological & pharmaceutical bulletin |
| 21244437 | 2011-10-01 | Inhibition of cytochrome P450 2A participating in coumarin 7-hydroxylation in pig liver microsomes | Journal of veterinary pharmacology and therapeutics |
| 20836976 | 2010-09-01 | Polymeric nanoparticle encapsulation of a naturally occurring plant scopoletin and its effects on human melanoma cell A375 | Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine |
| 20729216 | 2010-08-27 | The bell-shaped curve for peroxynitrite-mediated oxidation and nitration of NO/O2-* is alive and well | The Journal of biological chemistry |
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-115236936-A | A femtosecond laser curing cross-linked polyamic acid photoresist and its preparation method, use method and application | 2022-09-22 |
| CN-115236936-B | A femtosecond laser curing crosslinked polyamic acid photoresist and its preparation method, use method and application | 2022-09-22 |
| CN-114415471-B | A kind of siloxane-based two-photon photoresist and its preparation method, use method and application | 2022-03-01 |
| EP-4112600-A1 | Vinyl thianthrenium compound, process for its preparation and its use for transferring a vinyl group | 2021-07-03 |
| WO-2023280638-A1 | Vinyl thianthrenium compound, process for its preparation and its use for transferring a vinyl group | 2021-07-03 |
Applications of Fluorescent Probes & Dyes
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