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Coumarin 500 | CAS 52840-38-7
| Catalog Number | A17-0085 |
| Category | Laser Dyes |
| Molecular Formula | C12H10F3NO2 |
| Molecular Weight | 257.21 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Blue-green fluorescent probe used for photochemical and biological imaging. Exhibits high quantum yield and low photobleaching.
Chemical Information
Application
Computed Properties
Literatures
Patents
| Synonyms | 7-(ethylamino)-4-(trifluoromethyl)-2H-1-benzopyran-2-one |
| IUPAC Name | 7-(ethylamino)-4-(trifluoromethyl)chromen-2-one |
| Canonical SMILES | CCNC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F |
| InChI | InChI=1S/C12H10F3NO2/c1-2-16-7-3-4-8-9(12(13,14)15)6-11(17)18-10(8)5-7/h3-6,16H,2H2,1H3 |
| InChIKey | GZTMNDOZYLMFQE-UHFFFAOYSA-N |
Coumarin 500, a versatile chemical compound, is renowned for its diverse biological and industrial uses. Here are four key applications of Coumarin 500:
Fluorescent Labeling: A staple in biological and chemical assays, Coumarin 500 shines as a fluorescent dye, illuminating biomolecules like proteins and nucleic acids with its robust fluorescence. This luminous quality makes it the preferred choice for labeling biomolecules, aiding in their detection and quantification. Researchers employ Coumarin 500 in microscopy and flow cytometry to unravel intricate biological processes and molecular interactions, shedding light on the complex world of biomolecular dynamics.
Pharmaceutical Development: Pioneering the synthesis of anticoagulants and therapeutic agents, Coumarin 500 stands as a cornerstone in pharmaceutical innovation. Derivatives of Coumarin 500, such as warfarin, play a pivotal role in preventing blood clot formation in patients grappling with cardiovascular ailments. Its status as a lead compound fuels drug discovery efforts, laying the foundation for novel therapeutic molecules with enhanced efficacy and safety profiles.
Fragrance Industry: A coveted ingredient in the fragrance realm, Coumarin 500 lends its enchanting, sweet vanilla-like aroma to perfumes, lotions, and personal care products. Its alluring scent transforms ordinary products into olfactory delights, captivating consumers with its distinctive fragrance. Perfume and cosmetic manufacturers rely on Coumarin 500 to infuse their creations with an irresistible charm, elevating the sensory experience and setting their products apart in a competitive market.
Analytical Chemistry: A trusted ally in the realm of analytical chemistry, Coumarin 500 serves as the gold standard reference compound for calibrating instruments and validating analytical methods. Its well-documented properties and unwavering stability make it the ideal benchmark for various chromatographic and spectroscopic techniques. Analysts lean on Coumarin 500 to ensure the precision and reliability of their analytical measurements.
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 2 |
| Exact Mass | 257.06636305 g/mol |
| Monoisotopic Mass | 257.06636305 g/mol |
| Topological Polar Surface Area | 38.3Ų |
| Heavy Atom Count | 18 |
| Formal Charge | 0 |
| Complexity | 365 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 22417227 | 2012-07-01 | Role of solvation dynamics in excited state proton transfer of 1-naphthol in nanoscopic water clusters formed in a hydrophobic solvent | Photochemistry and photobiology |
| 21537495 | 2011-06-07 | Computer simulation to investigate the FRET application in DNA hybridization systems | Physical chemistry chemical physics : PCCP |
| 19789814 | 2009-10-01 | Temperature-dependent femtosecond-resolved hydration dynamics of water in aqueous guanidinium hydrochloride solution | Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology |
| 19038576 | 2009-03-01 | Optical properties and chemical behavior of Laser-dye Coumarin-500 and the influence of atmospheric corona discharges | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy |
| 15939425 | 2005-10-15 | Ultrafast dynamics in a nanocage of enzymes: solvation and fluorescence resonance energy transfer in reverse micelles | Journal of colloid and interface science |
| Publication Number | Title | Priority Date |
|---|---|---|
| US-2022334482-A1 | Photoresist top coating material for etching rate control | 2021-04-15 |
| WO-2022128052-A1 | Medicament for fighting inflammatory conditions of human skin | 2020-12-14 |
| US-2022153932-A1 | Prepolymers of 1,1-dicarbonyl substituted-1-alkene, methods to make them, polymers made from them and methods to make the polymer | 2020-11-18 |
| CA-3132429-A1 | Compositions and devices for containing medical fluids | 2020-10-02 |
| US-2022105001-A1 | Compositions and devices for containing medical fluids | 2020-10-02 |
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