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Coumarin 2 | CAS 26078-25-1
| Catalog Number | A17-0065 |
| Category | Laser Dyes |
| Molecular Formula | C13H15NO2 |
| Molecular Weight | 217.27 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Classic fluorescent coumarin dye used in organic lasers and fluorescence standards. Provides stable blue emission and excellent reproducibility.
Chemical Information
Product Specification
Application
Computed Properties
Patents
| Synonyms | Coumarin 450; 7-(ethylamino)-4,6-dimethyl-2H-1-benzopyran-2-one |
| IUPAC Name | 7-(ethylamino)-4,6-dimethylchromen-2-one |
| Canonical SMILES | CCNC1=C(C=C2C(=CC(=O)OC2=C1)C)C |
| InChI | InChI=1S/C13H15NO2/c1-4-14-11-7-12-10(5-9(11)3)8(2)6-13(15)16-12/h5-7,14H,4H2,1-3H3 |
| InChIKey | QZXAEJGHNXJTSE-UHFFFAOYSA-N |
| Signal | Warning |
| GHSHazardStatements | H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral] H312 (50%): Harmful in contact with skin [Warning Acute toxicity, dermal] H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H332 (50%): Harmful if inhaled [Warning Acute toxicity, inhalation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] |
| Precautionary Statement Codes | P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.) |
Coumarin 2, a versatile fluorescent dye, finds extensive utilization across diverse scientific and industrial domains. Here are four key applications of Coumarin 2:
Fluorescent Labeling: Within molecular biology and biochemistry realms, Coumarin 2 emerges as a pivotal tool for fluorescently labeling biomolecules like nucleic acids, proteins, and lipids. Its robust fluorescence properties enable the visualization and tracking of these entities within intricate biological systems. This application plays a crucial role in techniques such as fluorescence microscopy and flow cytometry, necessitating precise detection and quantification of labeled components.
Chemical Sensing: Embracing the capabilities of Coumarin 2, researchers delve into the realm of chemical sensors and biosensors, leveraging its fluorescence emission upon interaction with specific analytes. These sensors exhibit aptitude in detecting a myriad of chemical compounds, spanning ions, small molecules, and biochemical substances. By incorporating Coumarin 2 into sensor designs, scientists pave the way for sensitive and selective detection applications across environmental monitoring, medical diagnostics, and industrial quality control.
Energy Transfer Studies: Stepping into the realm of Förster Resonance Energy Transfer (FRET) studies, Coumarin 2 assumes a pivotal role in exploring biomolecular interactions. Serving as a fluorophore for either donor or acceptor roles, Coumarin 2 facilitates the measurement of distances and conformational transitions at a molecular scale. This technique plays a critical role in unraveling the intricacies of protein-protein interactions, enzyme mechanisms, and the dynamic structural attributes of nucleic acids.
Photodynamic Therapy: Delving into the realm of cancer treatment, Coumarin 2 stands out for its potential in photodynamic therapy (PDT), harnessing its ability to generate reactive oxygen species upon light activation at specific wavelengths. These reactive oxygen species are instrumental in selectively targeting and destroying cancer cells, thereby presenting a focused therapeutic solution that minimizes harm to surrounding healthy tissues. Leveraging the photochemical prowess of the dye, this application holds promise in revolutionizing targeted cancer therapies.
| XLogP3 | 2.5 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 2 |
| Exact Mass | 217.110278721 g/mol |
| Monoisotopic Mass | 217.110278721 g/mol |
| Topological Polar Surface Area | 38.3Ų |
| Heavy Atom Count | 16 |
| Formal Charge | 0 |
| Complexity | 311 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-113666898-A | Fluorescent probe for selective recognition of Hg2+ containing coumarin and preparation method thereof | 2021-07-01 |
| CN-113666898-B | Fluorescent probe for selective recognition of Hg2+ containing coumarin and preparation method thereof | 2021-07-01 |
| CN-112574280-B | Double-enzyme system probe and application thereof | 2020-12-21 |
| US-2022153932-A1 | Prepolymers of 1,1-dicarbonyl substituted-1-alkene, methods to make them, polymers made from them and methods to make the polymer | 2020-11-18 |
| WO-2022102675-A1 | Photosensitive element, method for producing cured product, method for producing cured product pattern, and method for producing wiring board | 2020-11-13 |
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