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IR 144 | CAS 54849-69-3
| Catalog Number | A17-0092 |
| Category | Laser Dyes |
| Molecular Formula | C50H58N4O8S2∙C6H15N |
| Molecular Weight | 1008.33 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
IR 144 is a fluorescent dye widely used in biomedical research and imaging. It is known for its ability to selectively stain mitochondria in living cells, allowing researchers to study mitochondrial dynamics and function. Additionally, IR 144 has shown promise as a potential therapeutic agent for targeting mitochondrial dysfunction in various diseases, including neurodegenerative disorders and cancer.
Chemical Information
Application
| Synonyms | 2-[2-[3-[[1,3-dihydro-1,1-dimethyl-3-(3-sulfopropyl)-2H-benz[e]indol-2-ylidene]ethylidene]-2-[4-(ethoxycarbonyl)-1-piperazinyl]-1-cyclopenten-1-yl]ethenyl]-1,1-dimethyl]-3-(3-sulfopropyl)-1H-benz[e]indolium hydroxide |
| Canonical SMILES | CCN(CC)CC.CCOC(=O)N1CC[N+](=C2C(=CC=C3C(C4=C(N3CCCS(=O)(=O)O)C=CC5=CC=CC=C54)(C)C)CCC2=CC=C6C(C7=C(N6CCCS(=O)(=O)[O-])C=CC8=CC=CC=C87)(C)C)CC1 |
| InChI | InChI=1S/C50H58N4O8S2.C6H15N/c1-6-62-48(55)52-31-29-51(30-32-52)47-37(21-25-43-49(2,3)45-39-15-9-7-13-35(39)19-23-41(45)53(43)27-11-33-63(56,57)58)17-18-38(47)22-26-44-50(4,5)46-40-16-10-8-14-36(40)20-24-42(46)54(44)28-12-34-64(59,60)61;1-4-7(5-2)6-3/h7-1 |
| InChIKey | CLQSKAVTPLZPDL-UHFFFAOYSA-N |
One of the primary applications of IR 144 is in the field of laser dye technology, particularly for dye lasers that operate in the near-infrared (NIR) spectrum. IR 144 is crucial because it allows lasers to emit light at specific NIR wavelengths that are not easily achievable with other dyes. These NIR wavelengths are vital for numerous scientific research applications, including spectroscopy, photonic devices, and medical diagnostics. The unique properties of IR 144, such as its high molar absorptivity and quantum yield, make it an invaluable component in these lasers, providing high efficiency and stability.
In biophotonics, IR 144 is extensively used due to its fluorescence properties. This dye is used in fluorescence microscopy, flow cytometry, and other imaging techniques to label and visualize biological specimens. Its ability to fluoresce in the NIR spectrum allows for deeper tissue penetration and reduced background interference, making it ideal for in vivo imaging. This application is particularly important in medical research, where detailed imaging of cellular and subcellular structures can provide insights into diseases and potential treatments.
IR 144 also finds application in the development of optical sensors. These sensors utilize the dye’s optical properties to detect changes in their environment, such as pH, ion concentration, or the presence of particular chemicals. The fluorescence response of IR 144 to these changes can be quantitatively measured, providing accurate and sensitive detection. This capability is crucial in environmental monitoring, industrial processes, and chemical research, where precise detection of various analytes is required.
Lastly, IR 144 is used in photodynamic therapy (PDT) for cancer treatment. In PDT, IR 144 acts as a photosensitizer that accumulates in cancer cells. When exposed to light of a specific wavelength, the dye generates reactive oxygen species that can kill cancer cells with minimal damage to surrounding healthy tissue. This targeted approach enhances the effectiveness of cancer treatment while reducing side effects, highlighting the dye’s significant role in advancing medical treatments.
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