Coumarin 519 | CAS 55804-65-4

Catalog Number	A17-0094
Category	Laser Dyes
Molecular Formula	C16H15NO4
Molecular Weight	285.29

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Product Introduction

Coumarin 519 is a synthetic fluorescent dye widely used in biomedical research. It serves as a valuable tool for studying drug distribution and pharmacokinetics, as well as for monitoring membrane potential and calcium signaling in live cells. Additionally, it finds applications in fluorescence microscopy, flow cytometry, and bioimaging techniques.

Chemical Information
Application

Synonyms	2,3,6,7-tetrahydro-11-oxo-1H,5H,11H-[1]benzopyrano[6,7,8-ij]quinolizine-10-carboxylic acid; Coumarin 343
Canonical SMILES	C1CC2=C3C(=C4C(=C2)C=C(C(=O)O4)C(=O)O)CCCN3C1
InChI	InChI=1S/C16H15NO4/c18-15(19)12-8-10-7-9-3-1-5-17-6-2-4-11(13(9)17)14(10)21-16(12)20/h7-8H,1-6H2,(H,18,19)
InChIKey	KCDCNGXPPGQERR-UHFFFAOYSA-N

Coumarin 519 is a fluorescent dye belonging to the coumarin family, a group of organic compounds that feature a benzopyrone structure. This structure is responsible for its notable photophysical properties, such as high fluorescence quantum yield, large Stokes shift, and excellent solubility in various solvents. These attributes make Coumarin 519 highly valuable in research and industrial applications, particularly in fields requiring sensitive detection and imaging techniques.

One of the key applications of Coumarin 519 is in the field of laser dyes. Due to its high fluorescence efficiency and stability under laser conditions, it is often used in dye lasers as a gain medium. This allows for the generation of laser beams at specific wavelengths suitable for diverse scientific and medical purposes, such as spectroscopy and photodynamic therapy. Its ability to provide tunable laser light is invaluable for precision in these applications.

Another significant application of Coumarin 519 is in fluorescence microscopy. This dye’s bright fluorescence and stability make it suitable for labeling biological samples, allowing researchers to visualize and track cellular components and biochemical processes in real-time. The high contrast and specificity provided by Coumarin 519 enhance the quality of imaging, facilitating advanced research in cellular biology and diagnostics.

Coumarin 519 is also utilized in the development of fluorescent sensors. Such sensors can detect ions, molecules, or environmental changes by exhibiting a change in fluorescence intensity or wavelength. This sensitivity and specificity make it ideal for monitoring chemical and biological processes in various environments, including industrial, environmental, and clinical settings.

Additionally, Coumarin 519 has applications in material science for the study and development of novel materials. Its fluorescence properties can be exploited to investigate the morphological and structural characteristics of materials at the nanoscale. This is crucial in designing new materials with specific optical, electronic, or mechanical properties for use in advanced technologies such as photovoltaics, light-emitting devices, and nanocomposites.