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PBFI AM | 124549-23-1
| Catalog Number | A14-0037 |
| Category | Calcium, Chloride Indictors and Other indicators |
| Molecular Formula | C58H62N2O24 |
| Molecular Weight | 1171.1 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A14-0037 | -- | $-- |
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Product Introduction
PBFI AM is a cell-permeable fluorescent probe for measuring potassium changes in cells and intracellular compartments. PBFI AM is hydrolyzed by intracellular esterases to release PBFI.
Chemical Information |
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|---|---|
| Synonyms | Potassium-binding Benzofuran Isophthalate Acetoxymethyl ester; 4,4'-[1,4,10,13-tetraoxa-7,16-diazacyclooctadecane-7,16-diylbis(5-methoxy-6,2-benzofurandiyl)]bis-1,3-benzenedicarboxylic acid, tetrakis[(acetyloxy)methyl] ester |
| Purity | ≥95% |
| Canonical SMILES | CC(=O)OCOC(=O)C1=CC(=C(C=C1)C2=CC3=CC(=C(C=C3O2)N4CCOCCOCCN(CCOCCOCC4)C5=C(C=C6C=C(OC6=C5)C7=C(C=C(C=C7)C(=O)OCOC(=O)C)C(=O)OCOC(=O)C)OC)OC)C(=O)OCOC(=O)C |
| InChI | InChI=1S/C58H62N2O24/c1-35(61)75-31-79-55(65)39-7-9-43(45(23-39)57(67)81-33-77-37(3)63)51-25-41-27-53(69-5)47(29-49(41)83-51)59-11-15-71-19-21-73-17-13-60(14-18-74-22-20-72-16-12-59)48-30-50-42(28-54(48)70-6)26-52(84-50)44-10-8-40(56(66)80-32-76-36(2)62)24-46(44)58(68)82-34-78-38(4)64/h7-10,23-30H,11-22,31-34H2,1-6H3 |
| InChI Key | AUKRBWNSOWVABU-UHFFFAOYSA-N |
| Appearance | Solid Powder |
- Product Specification
- Application
| Excitation | 336 nm |
| Emission | 480-557 nm |
| Storage | Store at -20°C |
PBFI AM, a potassium ion-specific fluorescent dye, finds diverse applications in scientific research.
Neuroscience Research: PBFI AM plays a vital role in neuroscience studies, enabling the monitoring of potassium ion dynamics within brain cells. This crucial function provides insights into neuronal signaling and activity, shedding light on synaptic transmission and neural excitability. By deciphering changes in potassium ion concentration, researchers delve deeper into the complexities of neurological disorders.
Cardiac Physiology Studies: Delving into cardiac research, PBFI AM emerges as an indispensable tool for investigating potassium ion fluxes during heart muscle contractions. This dye aids in unraveling the intricacies of cardiac electrophysiology, offering valuable insights into the impact of potassium channels on heart rhythms. Understanding these mechanisms is paramount for identifying targets to address arrhythmias and other cardiac ailments.
Pharmacological Screening: In the realm of drug discovery, PBFI AM serves as a crucial element in screening processes to evaluate the effects of pharmaceutical compounds on potassium ion channels. By leveraging this fluorescent dye, researchers can unravel how drugs modulate ion channel activity and influence cellular responses. This application stands at the forefront of medication development targeting ion channel dysfunctions prevalent in conditions like epilepsy and hypertension.
Plant Physiology Research: Within the domain of plant science, PBFI AM is a cornerstone for studying potassium ion transport and its impact on physiological processes such as stomatal movement and nutrient uptake. Through the visualization of potassium ion distribution in plant tissues, scientists gain valuable insights into how plants respond to environmental stressors. This knowledge not only enhances agricultural practices but also bolsters crop resilience in the face of various challenges, setting the stage for advancements in sustainable agriculture.
Applications of Fluorescent Probes & Dyes
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