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Mag-indo-1 tetrapotassium salt | CAS 132299-21-9
| Catalog Number | A14-0072 |
| Category | Calcium, Chloride and Other indicators |
| Molecular Formula | C21H14K4N2O9 |
| Molecular Weight | 594.74 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Mag-indo-1 tetrapotassium salt is a cell-impermeable fluorescent magnesium indicator.
Chemical Information
Application
Computed Properties
Patents
| Related CAS | 135446-92-3 (free base) |
| Synonyms | Magaptra-1 tetrapotassium salt; 2-[4-[bis(carboxylatomethyl)amino]-3-(carboxylatomethoxy)phenyl]-1H-indole-6-carboxylate tetrapotassium salt |
| IUPAC Name | tetrapotassium;2-[4-[bis(carboxylatomethyl)amino]-3-(carboxylatomethoxy)phenyl]-1H-indole-6-carboxylate |
| Canonical SMILES | C1=CC(=C(C=C1C2=CC3=C(N2)C=C(C=C3)C(=O)[O-])OCC(=O)[O-])N(CC(=O)[O-])CC(=O)[O-].[K+].[K+].[K+].[K+] |
| InChI | InChI=1S/C21H18N2O9.4K/c24-18(25)8-23(9-19(26)27)16-4-3-12(7-17(16)32-10-20(28)29)14-5-11-1-2-13(21(30)31)6-15(11)22-14;;;;/h1-7,22H,8-10H2,(H,24,25)(H,26,27)(H,28,29)(H,30,31);;;;/q;4*+1/p-4 |
| InChIKey | LQSATJAZEBYDQQ-UHFFFAOYSA-J |
Mag-indo-1 tetrapotassium salt, a fluorescent calcium indicator, finds widespread use in diverse scientific research applications. Here are four key applications of Mag-indo-1 tetrapotassium salt:
Intracellular Calcium Imaging: Leveraging Mag-indo-1 tetrapotassium salt for live-cell imaging enables the measurement of intracellular calcium levels. When stimulated by UV light, it emits fluorescence that fluctuates in response to calcium concentration, providing researchers with a real-time visualization of dynamic calcium signaling. This tool is indispensable for exploring cell physiology, deciphering signaling pathways, and probing neuronal activity with intricate detail.
Cardiovascular Research: Within the realm of cardiovascular investigations, Mag-indo-1 tetrapotassium salt serves as a pivotal resource for monitoring calcium transients in cardiac myocytes. Given calcium’s pivotal role in cardiac muscle contraction, tracking its dynamics offers profound insights into heart function and pathophysiology. This application is of paramount importance in unraveling the complexities of cardiac diseases and devising targeted therapeutic strategies.
Pharmacological Screening: In the domain of drug screening assays, the utility of Mag-indo-1 tetrapotassium salt shines through in evaluating the impacts of various compounds on calcium signaling. By monitoring changes in fluorescence, researchers can discern how different drugs modulate calcium channels, receptors, and transporters. This analytical approach aids in identifying prospective therapeutic candidates and elucidating their underlying mechanisms of action, fostering advancements in drug discovery.
Neuroscience: Within neuroscience research, the application of Mag-indo-1 tetrapotassium salt extends to investigating calcium dynamics in neurons and brain tissues. Given the crucial roles of calcium influx and efflux in neuronal signaling, synaptic transmission, and synaptic plasticity, this indicator facilitates a comprehensive exploration of neuronal communication, neurodegenerative conditions, and the effects of neuroactive substances. By delving deep into calcium-mediated processes, researchers can unravel the intricate workings of the brain and pave the way for innovative neurological insights.
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 10 |
| Rotatable Bond Count | 6 |
| Exact Mass | 593.9247560 g/mol |
| Monoisotopic Mass | 593.9247560 g/mol |
| Topological Polar Surface Area | 189Ų |
| Heavy Atom Count | 36 |
| Formal Charge | 0 |
| Complexity | 692 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 5 |
| Compound Is Canonicalized | Yes |
| Publication Number | Title | Priority Date |
|---|---|---|
| JP-2013215114-A | Intracellular ion imaging method, method for introducing dye for intracellular ion imaging into cells of biological sample, and container for dye introduction for intracellular ion imaging | 2012-04-05 |
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