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GSHtracer | CAS 1479071-34-5
| Catalog Number | A14-0003 |
| Category | Glutathione (GSH) Probes |
| Molecular Formula | C21H21N3O3 |
| Molecular Weight | 363.41 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
GSHtracer is a fluorescent probe for measuring of glutathione (GSH) levels.
Chemical Information
Product Specification
Application
Computed Properties
Literatures
| Synonyms | 2-Cyano-N,N-dimethyl-3-(2,3,6,7-tetrahydro-11-oxo-1H,5H,11H-[1]benzopyrano[6,7,8-ij]quinolizin-10-yl)-2-propenamide |
| Purity | ≥98% by HPLC |
| IUPAC Name | (E)-2-cyano-N,N-dimethyl-3-(4-oxo-3-oxa-13-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1,5,7,9(17)-tetraen-5-yl)prop-2-enamide |
| Canonical SMILES | CN(C)C(=O)C(=CC1=CC2=CC3=C4C(=C2OC1=O)CCCN4CCC3)C#N |
| InChI | InChI=1S/C21H21N3O3/c1-23(2)20(25)16(12-22)11-15-10-14-9-13-5-3-7-24-8-4-6-17(18(13)24)19(14)27-21(15)26/h9-11H,3-8H2,1-2H3/b16-11+ |
| InChIKey | YCXQIYZKBAKCHQ-LFIBNONCSA-N |
| Storage | Store at -20°C |
GSHtracer, a versatile tool for tracking and analyzing glutathione, a crucial antioxidant in diverse biological systems, exhibits a multitude of applications:
Oxidative Stress Research: Utilizing GSHtracer in the exploration of oxidative stress, a state characterized by the disparity between reactive oxygen species (ROS) and antioxidants within the body, researchers delve into the intricate dynamics. By monitoring glutathione levels, profound insights into cellular responses to oxidative insults are unearthed. This knowledge proves vital in unraveling the complexities of diseases linked to oxidative stress, including Alzheimer’s, Parkinson’s, and a spectrum of cardiovascular disorders.
Drug Metabolism Studies: Within pharmacology, GSHtracer serves as a pivotal tool for scrutinizing the involvement of glutathione in drug metabolism processes. Many pharmaceutical compounds undergo biotransformation, with glutathione conjugation playing a pivotal role in detoxification pathways. Leveraging GSHtracer, scientists meticulously observe the interactions between drugs and glutathione, contributing to the development of safer and more efficacious drug formulations.
Cancer Research: In the realm of oncology, GSHtracer emerges as a valuable asset enabling the monitoring of glutathione levels within tumor cells. Elevated glutathione levels in cancerous cells often confer resistance to chemotherapy regimens. By meticulously tracking these levels, researchers strategize interventions to modulate glutathione concentrations, thereby augmenting the effectiveness of anticancer therapies.
Cellular Health Monitoring: Deploying GSHtracer for the evaluation of cellular well-being under various experimental contexts, researchers gain insights into overall cellular health and viability. Glutathione levels within cells serve as a barometer of the cellular redox state and general health status. Employing GSHtracer in cell culture studies facilitates a nuanced understanding of how diverse treatments, toxins, or environmental stressors impact cellular functionality and survival.
| XLogP3 | 2.6 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 2 |
| Exact Mass | 363.15829154 g/mol |
| Monoisotopic Mass | 363.15829154 g/mol |
| Topological Polar Surface Area | 73.6Ų |
| Heavy Atom Count | 27 |
| Formal Charge | 0 |
| Complexity | 760 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 1 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 9426 | 1976-10-01 | The particulate superoxide-forming system from human neutrophils. Properties of the system and further evidence supporting its participation in the respiratory burst | The Journal of clinical investigation |
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