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Fura-FF AM | CAS 348079-12-9
| Catalog Number | A14-0027 |
| Category | Calcium, Chloride and Other indicators |
| Molecular Formula | C43H43F2N3O24 |
| Molecular Weight | 1023.8 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Fura-FF AM is a cell-permeable acetoxymethyl ester of fura-FF, a dluorescent calcium indicator. Fura-FF AM is hydrolyzed by intracellular esterases to release fura-FF in cells. Fura-FF is a difluorinated derivative of the calcium indicator fura-2. Compared to fura-2, fura-FF has a low affinity for calcium and is suitable for studying compartments with high concentrations of calcium.
Chemical Information
Product Specification
Application
| Synonyms | Fura-FF Acetoxymethyl ester; 2-[6-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-5-[2-[6-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-2,3-difluorophenoxy]ethoxy]-2-benzofuranyl]-5-oxazolecarboxylic acid(acetyloxy)methyl ester |
| Purity | ≥90% |
| Canonical SMILES | CC(=O)OCOC(=O)CN(CC(=O)OCOC(=O)C)C1=C(C(=C(C=C1)F)F)OCCOC2=C(C=C3C(=C2)C=C(O3)C4=NC=C(O4)C(=O)OCOC(=O)C)N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C |
| InChI | InChI=1S/C43H43F2N3O24/c1-23(49)61-18-66-36(54)14-47(15-37(55)67-19-62-24(2)50)30-7-6-29(44)40(45)41(30)60-9-8-59-33-10-28-11-34(42-46-13-35(72-42)43(58)70-22-65-27(5)53)71-32(28)12-31(33)48(16-38(56)68-20-63-25(3)51)17-39(57)69-21-64-26(4)52/h6-7,10-13H,8-9,14-22H2,1-5H3 |
| InChIKey | FPUWXSBNYDMTRN-UHFFFAOYSA-N |
| Appearance | Solid Powder |
| Excitation | 365 nm (no Ca2+), 339 nm (high Ca2+) |
| Emission | 514 nm (no Ca2+), 507 nm (high Ca2+) |
| Storage | Store at -20°C |
Fura-FF AM, a fluorescent calcium indicator widely utilized in scientific research, serves as a tool for measuring intracellular calcium levels. Here are four key applications of Fura-FF AM:
Neuroscience Research: Delving into the realm of neuronal activity, Fura-FF AM is a pivotal component in studying calcium dynamics within neurons. This exploration is essential for unraveling the intricacies of neural function, including signal transmission and neurotransmitter release. By monitoring fluctuations in calcium levels, researchers gain insight into synaptic plasticity, neuronal excitability, and the underlying mechanisms governing cognitive processes and neurological disorders.
Cardiac Physiology: In the domain of cardiac physiology, Fura-FF AM emerges as a crucial tool for tracking calcium fluxes in cardiac muscle cells. With calcium playing a fundamental role in regulating cardiac contractions and relaxations, abnormalities in calcium handling can precipitate heart conditions like arrhythmias and cardiomyopathies. Through the use of Fura-FF AM, scientists can visualize calcium transients and explore their contributions to both healthy and pathological cardiac functions.
Pharmacological Testing: Positioned at the forefront of pharmacological investigations, Fura-FF AM is instrumental in screening the effects of various drugs on calcium signaling pathways. By exposing Fura-FF AM-loaded cells to potential pharmacological agents, researchers can evaluate their impact on calcium levels and identify compounds that modulate calcium-dependent processes. This methodological approach is crucial in the pursuit of novel therapeutics targeting diseases linked to disturbances in calcium regulation.
Cell Biology Research: Within the realm of cell biology, Fura-FF AM serves as a valuable tool for examining the role of calcium in diverse cellular processes such as apoptosis, proliferation, and differentiation. By tracking calcium dynamics in real-time within live cells, researchers can investigate how different stimuli or environmental conditions influence calcium homeostasis. This data aids in deciphering cellular behavior and sheds light on the significance of calcium signaling in both physiological health and pathological conditions.
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