Fura-2 pentasodium salt | 96314-98-6

Catalog Number	A14-0133
Category	Calcium, Chloride and Other indicators
Molecular Formula	C29H22N3Na5O14
Molecular Weight	751.45

Catalog Number	Size	Price	Quantity
A14-0133	--	$--

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Product Introduction

Fura-2 pentasodium salt is a fluorescent ion indicator for intracellular calcium ion measurement.

Chemical Information
Application

Related CAS	96314-98-6 (free acid)
Canonical SMILES	CC1=CC(=C(C=C1)N(CC(=O)O)CC(=O)O)OCCOC2=C(C=C3C(=C2)C=C(O3)C4=NC=C(O4)C(=O)O)N(CC(=O)O)CC(=O)O
InChI	InChI=1S/C29H27N3O14/c1-15-2-3-17(31(11-24(33)34)12-25(35)36)20(6-15)43-4-5-44-21-7-16-8-22(28-30-10-23(46-28)29(41)42)45-19(16)9-18(21)32(13-26(37)38)14-27(39)40/h2-3,6-10H,4-5,11-14H2,1H3,(H,33,34)(H,35,36)(H,37,38)(H,39,40)(H,41,42)
InChI Key	YFHXZQPUBCBNIP-UHFFFAOYSA-N
Appearance	Solid Powder

Fura-2 pentasodium salt is a widely used fluorescent calcium indicator in bioscience research. Here are some key applications of Fura-2 pentasodium salt:

Intracellular Calcium Measurement: Fura-2 pentasodium salt is extensively used to measure intracellular calcium levels in various types of cells. By binding to calcium ions, it emits fluorescence that can be quantified using confocal microscopy or fluorometers. This helps in understanding calcium signaling pathways and their roles in cellular functions, such as muscle contraction and neurotransmitter release.

Drug Screening: In pharmacological research, Fura-2 pentasodium salt is utilized to screen potential drugs for their effects on cellular calcium dynamics. By monitoring changes in calcium levels in response to drug treatments, researchers can determine the efficacy and mechanisms of new therapeutic agents. This application is particularly valuable in cardiology and neuropharmacology, where calcium signaling is crucial.

Neuroscience: Fura-2 pentasodium salt is an important tool in neuroscience research for studying calcium dynamics in neurons. By imaging live neurons, scientists can observe synaptic activity, neuronal excitability, and calcium waves in real time. This provides critical insights into brain function, learning, memory, and the pathophysiology of neurological diseases.

Cardiac Research: In cardiac research, Fura-2 pentasodium salt is used to investigate calcium handling in heart cells. By visualizing calcium transients in cardiomyocytes, researchers can study excitation-contraction coupling, arrhythmias, and the effects of various drugs on heart function. This knowledge is essential for developing treatments for heart diseases and understanding cardiac physiology.

Applications of Fluorescent Probes & Dyes