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Fura-2 AM | CAS 108964-32-5
| Catalog Number | A14-0008 |
| Category | Calcium, Chloride and Other indicators |
| Molecular Formula | C44H47N3O24 |
| Molecular Weight | 1001.9 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Fura-2 AM is a cell-permeable fluorescent probe for detecting Ca2+ concentration.
Chemical Information
Product Specification
Application
| Synonyms | Fura-2 Acetoxymethyl ester; Fura-2 pentakis(acetoxymethyl) ester; 2-[6-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-5-[2-[2-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-5-methylphenoxy]ethoxy]-2-benzofuranyl]-5-oxazolecarboxylic acid, (acetyloxy)methyl ester |
| Purity | ≥95% |
| Canonical SMILES | CC1=CC(=C(C=C1)N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C)OCCOC2=C(C=C3C(=C2)C=C(O3)C4=NC=C(O4)C(=O)OCOC(=O)C)N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C |
| InChI | InChI=1S/C44H47N3O24/c1-25-7-8-32(46(16-39(53)65-20-60-26(2)48)17-40(54)66-21-61-27(3)49)35(11-25)58-9-10-59-36-12-31-13-37(43-45-15-38(71-43)44(57)69-24-64-30(6)52)70-34(31)14-33(36)47(18-41(55)67-22-62-28(4)50)19-42(56)68-23-63-29(5)51/h7-8,11-15H,9-10,16-24H2,1-6H3 |
| InChIKey | VPSRLGDRGCKUTK-UHFFFAOYSA-N |
| Appearance | Solid Powder |
| Excitation | 340-380 nm |
| Emission | 510 nm |
| Storage | Store at -20°C |
Fura-2 AM, a fluorescent calcium indicator, is instrumental in measuring calcium concentrations in live cells. Here are four key applications of Fura-2 AM:
Intracellular Calcium Imaging: Widely utilized in cell biology, Fura-2 AM enables the visualization and quantification of intracellular calcium levels. By loading cells with Fura-2 AM, researchers can dynamically track changes in calcium concentration in real-time using fluorescence microscopy. This technique is crucial for investigating intricate calcium signaling pathways and their intricate involvement in diverse cellular processes.
Neuroscience Research: Within neuroscience, Fura-2 AM serves as a vital tool for exploring the dynamic nature of calcium signaling within neurons. Calcium ions play a pivotal role in neurotransmitter release, synaptic plasticity, and neuronal excitability. Harnessing Fura-2 AM empowers scientists to observe calcium transients, unveiling the underlying mechanisms governing neural communication and dysfunction.
Cardiovascular Studies: In the realm of cardiovascular research, Fura-2 AM emerges as a key player in scrutinizing calcium handling in cardiac cells. Dysregulated calcium homeostasis is intricately linked to a spectrum of cardiac ailments, including arrhythmias and heart failure. By quantifying calcium levels in cardiomyocytes, researchers can pinpoint targets for therapeutic intervention, paving the way for novel strategies to combat heart-related conditions.
Pharmacological Screening: Fura-2 AM finds utility in high-throughput screening of compounds that influence calcium signaling pathways. Through evaluating the effects of various drugs on intracellular calcium levels, researchers can unearth potential therapeutic agents. This application proves particularly valuable in identifying modulators of calcium-related pathways as part of the drug discovery process.
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