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Fluo-3 sodium salt
| Catalog Number | A14-0022 |
| Category | Calcium, Chloride and Other indicators |
| Molecular Formula | C36H25Cl2N2Na5O13 |
| Molecular Weight | 879.4 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A14-0022 | -- | -- |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Fluo-3 is a fluorescent indicator for calcium that is commonly used in flow cytometry and cell-based experiments to detect changes in intracellular calcium levels.
Chemical Information
Product Specification
Application
| Related CAS | 123632-39-3 (free acid) |
| Synonyms | N-[2-[2-[2-[bis(carboxymethyl)amino]-5-(2,7-dichloro-6-oxido-3-oxo-3H-xanthen-9-yl)phenoxy]ethoxy]-4-methylphenyl]-N-(azanediyl)-diacetate, pentasodium salt |
| Purity | ≥90% |
| Canonical SMILES | CC1=CC(=C(C=C1)N(CC(=O)[O-])CC(=O)[O-])OCCOC2=C(C=CC(=C2)C3=C4C=C(C(=O)C=C4OC5=CC(=C(C=C53)Cl)[O-])Cl)N(CC(=O)[O-])CC(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+] |
| InChI | InChI=1S/C36H30Cl2N2O13.5Na/c1-18-2-4-24(39(14-32(43)44)15-33(45)46)30(8-18)51-6-7-52-31-9-19(3-5-25(31)40(16-34(47)48)17-35(49)50)36-20-10-22(37)26(41)12-28(20)53-29-13-27(42)23(38)11-21(29)36;;;;;/h2-5,8-13,41H,6-7,14-17H2,1H3,(H,43,44)(H,45,46)(H,47,48)(H,49,50);;;;;/q;5*+1/p-5 |
| InChIKey | QWVYPFKPTIDBTE-UHFFFAOYSA-I |
| Appearance | Solid Powder |
| Excitation | 488 nm |
| Emission | 526 nm |
| Storage | Store at -20°C |
Fluo-3 sodium salt, a fluorescent calcium indicator widely utilized in scientific research, finds diverse applications. Here are four key applications of Fluo-3 sodium salt:
Cellular Calcium Imaging: A cornerstone of cellular research, Fluo-3 sodium salt serves as a powerful tool for monitoring fluctuations in intracellular calcium concentrations within live cells. Upon binding with calcium, it emits a vibrant fluorescence, enabling researchers to visualize and quantify real-time calcium dynamics through fluorescence microscopy. This capability is crucial for investigating intricate cellular signaling pathways, muscle contractions, and other calcium-associated processes with unprecedented clarity.
Pharmacological Testing: Positioned at the forefront of drug discovery, Fluo-3 sodium salt plays a pivotal role in screening compounds that modulate calcium signaling pathways within cells. By evaluating the impact of potential drug candidates on calcium flux, researchers can pinpoint molecules with the potential to influence conditions like hypertension, cardiac arrhythmias, and neurological disorders. This application fuels the development of novel therapeutic agents tailored to specifically target calcium-related processes, driving innovation in medical treatment.
Neuroscience Research: Within the realm of neuroscience, Fluo-3 sodium salt emerges as an indispensable instrument for unraveling the complexities of synaptic activity and neural communication. Given that neurons heavily rely on calcium ions for neurotransmitter release and vital functions, visualizing calcium transients with Fluo-3 sodium salt offers invaluable insights into synaptic plasticity, neural circuits, and overall brain functionality. This technique proves instrumental in elucidating the mechanisms underpinning learning, memory formation, and neurological disorders with a nuanced and detailed approach.
High-Throughput Screening: In the domain of high-throughput screening assays, Fluo-3 sodium salt stands out as a key component for detecting and analyzing calcium flux across numerous samples simultaneously. By expediting the identification of bioactive compounds and genetic modulators affecting calcium-dependent pathways, this tool accelerates the pace of scientific discovery and pharmaceutical development. Its seamless integration with automated systems not only enhances efficiency but also ensures the reproducibility of results in large-scale biomedical research endeavors, opening new avenues for impactful research and technological advancements.
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