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Cyanine7 carboxylic acid | CAS 1628790-40-8
| Catalog Number | F02-0016 |
| Category | Cyanine7 |
| Molecular Formula | C37H45ClN2O2 |
| Molecular Weight | 585.22 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Free unactivated Cyanine7 dye carboxylic acid. Near-infrared fluorescent dye.For coupling and labeling reactions also consider using pre-activated Cyanine7 NHS ester, or water-soluble sulfo-Cyanine7 NHS ester.
Chemical Information
Product Specification
Application
Computed Properties
| Related CAS | 1628897-82-4 (without anion) 2241083-63-4 (inner salt) |
| Synonyms | 6-[(2E)-3,3-dimethyl-2-[2-[3-[(E)-2-(1,3,3-trimethylindol-1-ium-2-yl)ethenyl]cyclohex-2-en-1-ylidene]ethylidene]indol-1-yl]hexanoic acid;chloride; Cy7 carboxylic acid |
| Purity | NMR 1H, HPLC-MS (95%) |
| IUPAC Name | 6-[(2E)-3,3-dimethyl-2-[2-[3-[(E)-2-(1,3,3-trimethylindol-1-ium-2-yl)ethenyl]cyclohex-2-en-1-ylidene]ethylidene]indol-1-yl]hexanoic acid;chloride |
| Canonical SMILES | CC1(C2=CC=CC=C2[N+](=C1C=CC3=CC(=CC=C4C(C5=CC=CC=C5N4CCCCCC(=O)O)(C)C)CCC3)C)C.[Cl-] |
| InChI | InChI=1S/C37H44N2O2.ClH/c1-36(2)29-16-8-10-18-31(29)38(5)33(36)23-21-27-14-13-15-28(26-27)22-24-34-37(3,4)30-17-9-11-19-32(30)39(34)25-12-6-7-20-35(40)41;/h8-11,16-19,21-24,26H,6-7,12-15,20,25H2,1-5H3;1H |
| InChIKey | FOVQXMYLXAXGJR-UHFFFAOYSA-N |
| Solubility | soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water |
| Appearance | green powder |
| ε, L⋅mol-1⋅cm-1 | 199000 |
| Excitation | 750 |
| Emission | 773 |
| Storage | 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate. |
Cyanine7 carboxylic acid, a near-infrared fluorescent dye with unique properties, finds diverse applications in scientific research. Here are four key applications of Cyanine7 carboxylic acid:
Immunofluorescence Imaging: Utilizing Cyanine7 carboxylic acid in immunofluorescence techniques enables the precise labeling of antibodies for detecting specific proteins within cells and tissues. Its near-infrared characteristics facilitate deep tissue penetration and minimal background fluorescence, thereby enhancing image clarity. Researchers leverage this dye to explore protein localization, expression patterns, and intricate cellular interactions.
Molecular Imaging: In the realm of preclinical studies, Cyanine7 carboxylic acid plays a pivotal role in whole-body imaging of small animals. By conjugating the dye to targeting molecules, like antibodies or peptides, researchers can visualize and track biological processes in vivo. This approach proves invaluable in cancer research, aiding in the identification of tumor sites and the monitoring of disease progression with exceptional accuracy.
Fluorescence-Guided Surgery: The integration of Cyanine7-labelled compounds in fluorescence-guided surgery marks a significant advancement in enhancing the precision of tumor resections. Surgeons can now visualize cancerous tissues in real-time under near-infrared light, enabling more accurate removal while preserving healthy tissues. This application not only elevates surgical outcomes but also diminishes the chances of tumor recurrence, revolutionizing the field of oncological surgery.
Pharmaceutical Development: Within the realm of drug delivery system development, Cyanine7 carboxylic acid fulfills a crucial role as a fluorescent marker for tracking the distribution and accumulation of therapeutic agents. Researchers can evaluate the efficacy of drug delivery mechanisms by observing fluorescence signals in target tissues. This data plays a pivotal role in refining drug formulations and optimizing delivery strategies, propelling advancements in pharmaceutical development.
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 9 |
| Exact Mass | 584.3169564 g/mol |
| Monoisotopic Mass | 584.3169564 g/mol |
| Topological Polar Surface Area | 43.6Ų |
| Heavy Atom Count | 42 |
| Formal Charge | 0 |
| Complexity | 1130 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 2 |
| Undefined Bond Stereocenter Count | 1 |
| Covalently-Bonded Unit Count | 2 |
| Compound Is Canonicalized | Yes |
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