Calcein | 1461-15-0
Catelog Number | A14-0009 |
Category | Calcium, Chloride Indictors and Other indicators |
Molecular Formula | C30H26N2O13 |
Molecular Weight | 622.53 |
Catalog Number | Size | Price | Quantity |
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A14-0009 | -- | $-- |
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Product Introduction
Calcein is a fluorescent calcium indicator. It can be used for the fluorometric determination of calcium and EDTA titration of calcium.
Chemical Information |
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Related CAS | 4370-08-5 (Deleted CAS) 359900-38-2 (Alternate CAS) |
Synonyms | Fluorescein Complexone; Fluorexon; Oftasceine; Fluorescein, 2',7'-bis[[bis(carboxymethyl)amino]methyl]-; N,N'-[(3',6'-Dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-2',7'-diyl)bis(methylene)]bis[N-(carboxymethyl)glycine]; 2,2',2'',2'''-(((3',6'-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-2',7'-diyl)bis(methylene))bis(azanetriyl))tetraacetic acid; 2,7-Bis[N,N-bis(carboxymethyl)aminomethylene]fluorescein; Acetic acid, [(3',6'-dihydroxy-2',7'-fluorandiyl)bis(methylenenitrilo)]tetra-; NSC 298193 |
Purity | ≥95% |
IUPAC Name | 2-[[7'-[[bis(carboxymethyl)amino]methyl]-3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-2'-yl]methyl-(carboxymethyl)amino]acetic acid |
Canonical SMILES | C1=CC=C2C(=C1)C(=O)OC23C4=CC(=C(C=C4OC5=CC(=C(C=C35)CN(CC(=O)O)CC(=O)O)O)O)CN(CC(=O)O)CC(=O)O |
InChI | InChI=1S/C30H26N2O13/c33-21-7-23-19(5-15(21)9-31(11-25(35)36)12-26(37)38)30(18-4-2-1-3-17(18)29(43)45-30)20-6-16(22(34)8-24(20)44-23)10-32(13-27(39)40)14-28(41)42/h1-8,33-34H,9-14H2,(H,35,36)(H,37,38)(H,39,40)(H,41,42) |
InChI Key | DEGAKNSWVGKMLS-UHFFFAOYSA-N |
Solubility | Soluble in Water |
Density | 1.74±0.1 g/cm3 |
Appearance | Yellow-orange to Orange-brown Powder |
Boiling Point | 952.7±65.0°C at 760 mmHg |
Melting Point | 200°C |
Product Specification |
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Excitation | 494 nm |
Emission | 517 nm |
Storage | Store at RT |
Application | Used as an indicator of calcium and in biological research. |
Signal | Warning |
GHS Hazard Statements | H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal] H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] |
Precautionary Statement Codes | P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.) |
Computed Properties | |
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XLogP3 | -3.1 |
Hydrogen Bond Donor Count | 6 |
Hydrogen Bond Acceptor Count | 15 |
Rotatable Bond Count | 12 |
Exact Mass | 622.14348889 g/mol |
Monoisotopic Mass | 622.14348889 g/mol |
Topological Polar Surface Area | 232Ų |
Heavy Atom Count | 45 |
Formal Charge | 0 |
Complexity | 1070 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 1 |
Compound Is Canonicalized | Yes |
Literatures
PMID | Publication Date | Title | Journal |
---|---|---|---|
29174985 | 2018-03-01 | Role of P-glycoprotein in deoxynivalenol-mediated in vitro toxicity | Toxicology letters |
26454883 | 2016-01-01 | Nrf2 Regulates the Sensitivity of Mouse Keratinocytes to Nitrogen Mustard via Multidrug Resistance-Associated Protein 1 (Mrp1) | Toxicological sciences : an official journal of the Society of Toxicology |
23896552 | 2013-11-01 | Antifungal effect and pore-forming action of lactoferricin B like peptide derived from centipede Scolopendra subspinipes mutilans | Biochimica et biophysica acta |
23816874 | 2013-10-01 | Antifungal property of hibicuslide C and its membrane-active mechanism in Candida albicans | Biochimie |
23643888 | 2013-08-01 | Isolation of (-)-olivil-9'-O-β-d-glucopyranoside from Sambucus williamsii and its antifungal effects with membrane-disruptive action | Biochimica et biophysica acta |
Patents
Publication Number | Title | Priority Date |
---|---|---|
JP-2022163215-A | Neurogenesis stimulant, internal medicine, medium additive, cell diluent additive, medium and cell diluent | 2022-08-18 |
CN-115040528-B | The application of diflavin D and anti-tumor metastasis drug | 2022-08-17 |
CN-115109753-A | A three-dimensional bioprinted gallbladder cancer model and its construction method | 2022-08-04 |
CN-115093961-A | A multi-volume droplet digital LAMP nucleic acid absolute quantitative detection device, method and application | 2022-07-29 |
CN-115232195-A | Oligopeptide two-dimensional nanomaterials and their applications | 2022-07-25 |
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