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Zinquin ethyl ester | CAS 181530-09-6
| Catalog Number | A14-0013 |
| Category | Calcium, Chloride and Other indicators |
| Molecular Formula | C21H22N2O5S |
| Molecular Weight | 414.48 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A14-0013 | -- | -- |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Zinquin ethyl ester is a cell-permeable fluorescent indicator for Zn2+. It is cleaved by cytosolic esterases to prevent its efflux across the plasma membrane. Zinquin ethyl ester has been used to monitor intracellular zinc fluxes associated with apoptosis.
Chemical Information
Product Specification
Application
Computed Properties
Patents
| Synonyms | 2-[[2-methyl-8-[[(4-methylphenyl)sulfonyl]amino]-6-quinolinyl]oxy]-acetic acid, ethyl ester; Acetic acid, 2-[[2-methyl-8-[[(4-methylphenyl)sulfonyl]amino]-6-quinolinyl]oxy]-, ethyl ester; Acetic acid, [[2-methyl-8-[[(4-methylphenyl)sulfonyl]amino]-6-quinolinyl]oxy]-, ethyl ester; Ethyl 2-[[2-methyl-8-[[(4-methylphenyl)sulfonyl]amino]-6-quinolinyl]oxy]acetate |
| Purity | ≥98% |
| IUPAC Name | ethyl 2-[2-methyl-8-[(4-methylphenyl)sulfonylamino]quinolin-6-yl]oxyacetate |
| Canonical SMILES | CCOC(=O)COC1=CC(=C2C(=C1)C=CC(=N2)C)NS(=O)(=O)C3=CC=C(C=C3)C |
| InChI | InChI=1S/C21H22N2O5S/c1-4-27-20(24)13-28-17-11-16-8-7-15(3)22-21(16)19(12-17)23-29(25,26)18-9-5-14(2)6-10-18/h5-12,23H,4,13H2,1-3H3 |
| InChIKey | KCASTCXJTDRDFT-UHFFFAOYSA-N |
| Solubility | Soluble in Chloroform (Slightly), Methanol (Slightly, Heated) |
| Density | 1.313±0.06 g/cm3 |
| Appearance | White to Off-white Solid |
| Boiling Point | 578.0±60.0°C at 760 mmHg |
| Excitation | 368 nm |
| Emission | 490 nm |
| Storage | Store at -20°C |
Zinquin ethyl ester, a fluorescent zinc ion indicator commonly utilized in biological research, serves as a versatile tool in various scientific investigations. Here are four key applications of Zinquin ethyl ester:
Intracellular Zinc Imaging: Widely employed for visualizing and quantifying zinc ion concentrations within cells, Zinquin ethyl ester enables researchers to monitor dynamic changes in intracellular zinc levels through fluorescence microscopy. This application plays a pivotal role in unraveling the significance of zinc in diverse cellular processes, such as enzyme functionality and signal transduction dynamics.
Neurobiology: In the realm of neurobiology, Zinquin ethyl ester facilitates the exploration of zinc dynamics within neuronal cells. Zinc signaling is essential for neurotransmission and synaptic plasticity, and this ester allows real-time visualization of zinc distribution in neurons, offering insights into the ramifications of zinc dysregulation in neurodegenerative conditions like Alzheimer’s and Parkinson’s disease.
Oxidative Stress Research: Scientists utilize Zinquin ethyl ester in the investigation of zinc’s involvement in oxidative stress responses and antioxidant defense mechanisms. By tracking zinc ions, researchers can probe how zinc contributes to counteracting oxidative damage and maintaining redox balance. This application holds particular significance in elucidating the pathophysiology of diseases associated with oxidative stress, such as cancer and cardiovascular disorders.
Pharmacological Screening: Playing a crucial role in pharmacological studies, Zinquin ethyl ester aids in the identification of compounds that modulate intracellular zinc levels. Through high-throughput screening assays incorporating this ester, scientists can pinpoint potential drugs that either chelate or release zinc ions, paving the way for the development of therapeutic agents targeting zinc homeostasis in a spectrum of diseases.
| XLogP3 | 3.7 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 8 |
| Exact Mass | 414.12494298 g/mol |
| Monoisotopic Mass | 414.12494298 g/mol |
| Topological Polar Surface Area | 103Ų |
| Heavy Atom Count | 29 |
| Formal Charge | 0 |
| Complexity | 642 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
| Publication Number | Title | Priority Date |
|---|---|---|
| WO-2022221693-A1 | Aluminosilicate nanoparticle sensors and uses thereof | 2021-04-15 |
| CA-3137789-A1 | Method for production of liposomes | 2019-05-07 |
| US-2022241203-A1 | Method for production of liposomes | 2019-05-07 |
| WO-2019222622-A1 | Sperm fertility capacity test and sperm decapacitating supplement | 2018-05-18 |
| US-2021270815-A1 | Sperm fertility capacity test and sperm decapacitating supplement | 2018-05-18 |
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