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Linsidomine hydrochloride | 16142-27-1
| Catalog Number | A03-0004 |
| Category | Nitric Oxide (NO) & Reactive Oxygen Species (ROS) |
| Molecular Formula | C6H11ClN4O2 |
| Molecular Weight | 206.63 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A03-0004 | -- | $-- |
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Product Introduction
An impurity of Molsidomine. Molsidomine is a long-acting vasodilator primarily used for the treatment of angina pectoris, heart failure, and cardiovascular diseases following myocardial infarction.
Chemical Information |
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|---|---|
| Related CAS | 744953-71-7 (free base) 33876-97-0 (free base inner salt) |
| Synonyms | 1,2,3-Oxadiazolium, 5-amino-3-(4-morpholinyl)-, chloride (1:1); Sydnone imine, 3-(4-morpholinyl)-, monohydrochloride; Sydnone imine, 3-morpholino-, monohydrochloride; 3-Morpholinosydnone imine monohydrochloride; 3-Morpholinosydnonimine hydrochloride; 5-Amino-3-(4-morpholinyl)-1,2,3-oxadiazolium chloride; Linsidomine chlorhydrate |
| Purity | ≥95% |
| IUPAC Name | 3-morpholin-4-yloxadiazol-3-ium-5-amine;chloride |
| Canonical SMILES | C1COCCN1[N+]2=NOC(=C2)N.[Cl-] |
| InChI | InChI=1S/C6H11N4O2.ClH/c7-6-5-10(8-12-6)9-1-3-11-4-2-9;/h5H,1-4,7H2;1H/q+1;/p-1 |
| InChI Key | ZRFWHHCXSSACAW-UHFFFAOYSA-M |
| Solubility | Soluble in DMSO, Water |
| Appearance | White Solid |
| Melting Point | 171-173 °C (dec.) |
- Product Specification
- Application
| Storage | Store at -20 °C |
Molsidomine Impurity A plays a crucial role in the pharmaceutical industry, particularly in the development of cardiovascular drugs. Its ability to modulate Reactive Oxygen Species (ROS) levels can be leveraged in formulations aimed at treating conditions such as angina and hypertension. By understanding how this impurity interacts with ROS, researchers can optimize drug efficacy and reduce potential side effects. This makes Molsidomine Impurity A a valuable component in the formulation of safer, more effective cardiovascular therapies.
In addition to its applications in cardiovascular therapeutics, Molsidomine Impurity A is also being investigated for its potential in cancer research. ROS are known to influence tumor progression and metastasis, and Molsidomine Impurity A can be utilized to study these mechanisms. By modulating ROS levels, this impurity may help in understanding tumor microenvironments and the pathways involved in cancer cell survival. Consequently, it may serve as a target for novel cancer therapies that aim to exploit ROS dynamics for improved treatment outcomes.
Molsidomine Impurity A is also relevant in the context of neurodegenerative diseases. Research indicates that ROS play a significant role in the pathophysiology of conditions like Alzheimer's and Parkinson's disease. The ability of Molsidomine Impurity A to influence oxidative stress makes it a potential candidate for studies focusing on neuroprotection. By investigating its effects on ROS levels in neuronal cells, scientists can explore new avenues for therapeutic interventions that aim to mitigate oxidative damage in neurodegenerative disorders.
Lastly, Molsidomine Impurity A finds applications in the field of toxicology, particularly in assessing the oxidative stress response in various biological systems. By serving as a reference standard for ROS generation, it can be employed in toxicity studies to evaluate the oxidative stress mechanisms in cells exposed to different toxic agents. This information is critical for the development of safety profiles for new drugs and for understanding the broader implications of oxidative stress in various environmental and clinical contexts.
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