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SNOG | CAS 57564-91-7
| Catalog Number | A03-0003 |
| Category | NO & ROS Probes |
| Molecular Formula | C10H16N4O7S |
| Molecular Weight | 336.32 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
SNOG is an amino acid nitric oxide donor that acts as a smooth muscle relaxant and platelet aggregation inhibitor. It also inhibits NF-κB activation, endothelial cell proliferation and cathepsin B (cysteine proteases).
Chemical Information
Product Specification
Application
| Synonyms | S-Nitroso-L-glutathione;S-Nitrosoglutathione; Nitrosoglutathione; Glutathione thionitrite; GNSO |
| Purity | ≥97% |
| IUPAC Name | (2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-3-nitrososulfanyl-1-oxopropan-2-yl]amino]-5-oxopentanoic acid |
| Canonical SMILES | C(CC(=O)NC(CSN=O)C(=O)NCC(=O)O)C(C(=O)O)N |
| InChI | InChI=1S/C10H16N4O7S/c11-5(10(19)20)1-2-7(15)13-6(4-22-14-21)9(18)12-3-8(16)17/h5-6H,1-4,11H2,(H,12,18)(H,13,15)(H,16,17)(H,19,20)/t5-,6-/m0/s1 |
| InChIKey | HYHSBSXUHZOYLX-WDSKDSINSA-N |
| Solubility | Soluble in water and DMSO |
| Appearance | Pink Solid |
| Storage | Store at-10 to-35 °C, Desiccate |
Nitric oxide (NO) donors such as S-nitrosoglutathione (SNOG) are utilized in medical research for their ability to generate reactive oxygen species (ROS). One of the foremost applications of SNOG is in cardiovascular therapy. The steady release of NO from SNOG can effectively dilate blood vessels, improving blood flow and reducing hypertension. This vasodilatory effect is particularly beneficial in treating conditions like angina, where improved blood flow can alleviate symptoms and prevent severe cardiovascular events. Moreover, NO donors have been shown to inhibit platelet aggregation, thereby reducing the risk of thrombosis. This dual benefit of vasodilation and antithrombotic activity makes SNOG a valuable tool in cardiovascular therapeutics.
Another crucial application of SNOG lies in its roles in cancer research and therapy. Reactive oxygen species, including those generated by SNOG, can induce oxidative stress in cancer cells, leading to cell death. This is particularly effective in targeting cancer cells due to their higher metabolic rates and increased production of ROS compared to normal cells. By enhancing oxidative stress, SNOG can selectively induce apoptosis in malignant cells without significantly affecting healthy tissue. Additionally, research has shown that SNOG can enhance the efficacy of chemotherapy and radiotherapy by sensitizing cancer cells to these treatments, thereby potentially reducing the required doses and associated side effects.
SNOG is also employed in the field of neurobiology to investigate mechanisms of neurodegeneration and potential treatments. The brain is particularly susceptible to oxidative damage due to its high oxygen consumption and lipid-rich environment. By using SNOG to generate controlled levels of ROS, researchers can study oxidative stress’s impact on neuronal cells, aiding in the understanding of diseases such as Alzheimer’s and Parkinson’s. Furthermore, SNOG’s ability to modulate NO levels provides insights into neuronal communication and neuroinflammation, contributing to the development of neuroprotective strategies that could mitigate or prevent neurodegenerative conditions.
The anti-inflammatory properties of SNOG are leveraged in research focused on immune modulation and inflammatory diseases. SNOG releases NO, which can downregulate pro-inflammatory cytokines and inhibit the expression of adhesion molecules involved in leukocyte migration. This mechanism is beneficial in controlling conditions characterized by chronic inflammation, such as rheumatoid arthritis and inflammatory bowel disease. By reducing inflammation, SNOG can alleviate symptoms and improve patients’ quality of life. Additionally, its ROS-generating properties help in understanding the balance between oxidative stress and immune responses, facilitating the development of therapeutic approaches that aim to harness or mitigate oxidative stress for better disease management.
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