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TCO-PEG-TCO, MW 5,000
| Catalog Number | R15-0006 |
| Category | TCO |
| Molecular Formula | C22H36N2O5 |
| Molecular Weight | 408.5 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| R15-0006 | -- | $-- |
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Product Introduction
TCO-PEG-TCO, MW 5,000 is a tetrazine reactive PEG polymer forming a stable dihydropyridazine bond. TCO-Tz ligation is a bioorthogonal reaction which has high selectivity and exceptional kinetics. Bioconjugations are often constrained by the low concentration of biomolecule; thus, a highly reactive TCO-Tz ligation is a very promising technique for this application.
Chemical Information |
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|---|---|
| IUPAC Name | [(4E)-cyclooct-4-en-1-yl] N-[2-[2-[[(4E)-cyclooct-4-en-1-yl]oxycarbonylamino]ethoxy]ethyl]carbamate |
| Canonical SMILES | C1CC=CCCC(C1)OC(=O)NCCOCCNC(=O)OC2CCCC=CCC2 |
| InChI | InChI=1S/C22H36N2O5/c25-21(28-19-11-7-3-1-4-8-12-19)23-15-17-27-18-16-24-22(26)29-20-13-9-5-2-6-10-14-20/h1-3,5,19-20H,4,6-18H2,(H,23,25)(H,24,26)/b3-1+,5-2+ |
| InChI Key | QUIRYKXVXHEQKK-MGBLWKCQSA-N |
- Product Specification
- Application
| Storage | -20 °C |
TCO-PEG-TCO MW 5000, a bioconjugation reagent boasting bioorthogonal click chemistry properties, finds wide-ranging utility in biotechnological and biomedical arenas. Here, delve into four key applications of TCO-PEG-TCO MW 5000:
Drug Delivery: Employing TCO-PEG-TCO for targeted drug delivery enhances the precision of therapeutic agent transport to specific anatomical sites. By associating the reagent with drugs or nanoparticles, researchers elevate the bioavailability and site-specific release of these agents, potentially revolutionizing treatment efficacy while minimizing adverse effects.
Biomolecular Labeling: Within molecular biology, TCO-PEG-TCO serves as a pivotal tool for meticulously labeling biomolecules such as proteins, peptides, or nucleic acids. Leveraging its click chemistry properties, researchers engage in rapid, exceptionally selective conjugation reactions. This labeling methodology is indispensable for scrutinizing biomolecular interactions, tracking dynamic biological processes, and forging innovative diagnostic assays.
Imaging and Diagnostics: TCO-PEG-TCO drives the evolution of cutting-edge imaging probes and diagnostic instruments. Through conjugating fluorescent dyes or contrast agents to TCO-PEG-TCO, researchers fashion highly precise imaging agents that amplify the detection and visualization of biological structures and diseases. This advancement proves particularly invaluable in cancer imaging, where both specificity and sensitivity play pivotal roles.
Bioconjugate Stabilization: The inclusion of PEG in TCO-PEG-TCO bolsters the biocompatibility and solubility of conjugated molecules, heightening their stability and circulation duration within biological milieus. This fortification proves advantageous in contexts like therapeutic protein delivery, where prolonged stability and diminished immunogenicity rank as desired attributes. The prolonged half-life of the bioconjugate could potentially enhance therapeutic effectiveness, culminating in improved patient outcomes.
Computed Properties | |
|---|---|
| XLogP3 | 4.1 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 10 |
| Exact Mass | 408.26242225 g/mol |
| Monoisotopic Mass | 408.26242225 g/mol |
| Topological Polar Surface Area | 85.9Ų |
| Heavy Atom Count | 29 |
| Formal Charge | 0 |
| Complexity | 489 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 2 |
| Defined Bond Stereocenter Count | 2 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Applications of Fluorescent Probes & Dyes
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