Propargyl-NHS Ester

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Propargyl-NHS Ester

Propargyl-NHS Ester | 1174157-65-3

Catalog Number R01-0230
Category Alkynes
Molecular Formula C10H11NO5
Molecular Weight 225.20
Catalog Number Size Price Quantity
R01-0230 1 g $428
R01-0230 -- --

Product Introduction

Propargyl-NHS ester is an indispensable small molecule tool in the biomedical field and is a key coupling agent that promotes bioconjugation reactions. This compound labels a range of biomolecules including proteins and peptides, facilitating their unambiguous identification and meticulous monitoring. With its sheer versatility, Propargyl-NHS Ester coordinates a range of tasks, including drug delivery systems, diagnostics and targeted therapies.

Chemical Information

Synonyms Propargyl-PEG1-NHS ester; 2,5-dioxopyrrolidin-1-yl 3-(prop-2-ynyloxy)propanoate; N-Succinimidyl 3-(propargyloxy)propionate; Propargyl-N-hydroxysuccinimidyl ester
Purity 95% by NMR
IUPAC Name (2,5-dioxopyrrolidin-1-yl) 3-prop-2-ynoxypropanoate
Canonical SMILES C#CCOCCC(=O)ON1C(=O)CCC1=O
InChI InChI=1S/C10H11NO5/c1-2-6-15-7-5-10(14)16-11-8(12)3-4-9(11)13/h1H,3-7H2
InChI Key WKIKHHMUNOVQLD-UHFFFAOYSA-N
Solubility Soluble in DMSO, DCM, DMF
Density 1.32±0.1 g/cm3
Appearance Colorless to Light Yellow Liquid
Boiling Point 351.2±48.0 °C at 760 mmHg
Melting Point 36-41 °C
  • Product Specification
  • Application
Excitation 555
Emission 580
Storage Store at -20 °C

Propargyl-NHS Ester, a versatile chemical reagent widely applied in bioconjugation and molecular biology, boasts a myriad of key applications:

Protein Labeling: Harnessing the power of Propargyl-NHS Ester, researchers can selectively affix alkyne groups to proteins, paving the way for further functionalization through click chemistry. This strategic approach allows for the meticulous examination of protein interactions, localization, and function in a precise manner. The proteins conjugated with this reagent can be discerned and scrutinized using bioorthogonal reactions in tandem with azide-functionalized probes, unlocking a deeper understanding of cellular processes at the molecular level.

Immunoassay Development: Delving into immunoassay development, Propargyl-NHS Ester emerges as a pivotal tool for labeling antibodies with alkyne groups, facilitating the construction of diverse immunoassays of enhanced sensitivity. These labeled antibodies, when paired with azide-modified reporters, boost detection capabilities crucial for diagnostic applications and cutting-edge biomarker research.

Peptide Synthesis: In the realm of peptide chemistry, the utilization of Propargyl-NHS Ester elevates the modification of peptides through the introduction of alkyne groups. This functional moiety sets the stage for click chemistry-driven attachment of various reporter molecules and additional functional entities. The modified peptides engineered using this approach find applications in structural studies, drug discovery endeavors, and the development of innovative therapeutics, showcasing the versatility and ingenuity embedded in peptide research.

Surface Functionalization: Propargyl-NHS Ester emerges as a game-changer in surface functionalization strategies tailored for biosensor and biochip applications. By anchoring alkyne-functionalized biomolecules onto surfaces, researchers create tailored and stable interfaces vital for precise and specific biological detection mechanisms. This groundbreaking approach underpins the development of diagnostic tools and analytical platforms essential for advancing biomedical research into uncharted territories of precision and accuracy.

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