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DBCO-sulfo-NHS Ester | CAS 1400191-52-7
| Catalog Number | R01-0433 |
| Category | Cycloalkyne Dyes (DBCO) |
| Molecular Formula | C25H21N2NaO8S |
| Molecular Weight | 532.50 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
DBCO-sulfo-NHS Ester is a water-soluble ADC linker with DBCO for copper-free click chemistry and NHS ester for efficient amine coupling, optimizing antibody-payload conjugation stability and hydrophilicity.
Chemical Information
Product Specification
Computed Properties
Patents
| Synonyms | 6-oxo-6-(dibenzo[b,f]azacyclooct-4-yn-1-yl)-caproic acid sulfo-N-hydroxysuccinimide ester, sodium salt; DBCO-Sulfo-NHS ester (sodium) |
| Purity | >98.0% |
| Shelf Life | ≥ 2 years |
| IUPAC Name | |
| Canonical SMILES | C1C(C(=O)N(C1=O)OC(=O)CCCCC(=O)N2CC3=CC=CC=C3C#CC4=CC=CC=C42)S(=O)(=O)[O-].[Na+] |
| InChI | InChI=1S/C25H22N2O8S.Na/c28-22(11-5-6-12-24(30)35-27-23(29)15-21(25(27)31)36(32,33)34)26-16-19-9-2-1-7-17(19)13-14-18-8-3-4-10-20(18)26;/h1-4,7-10,21H,5-6,11-12,15-16H2,(H,32,33,34);/q;+1/p-1 |
| InChIKey | QXKHPYSXPCJSPR-UHFFFAOYSA-M |
| Solubility | 10 mm in DMSO |
| Storage | Store at -20°C |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 8 |
| Exact Mass | 532.09163109 g/mol |
| Monoisotopic Mass | 532.09163109 g/mol |
| Topological Polar Surface Area | 150Ų |
| Heavy Atom Count | 37 |
| Formal Charge | 0 |
| Complexity | 1080 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 2 |
| Compound Is Canonicalized | Yes |
| Publication Number | Title | Priority Date |
|---|---|---|
| WO-2022258829-A1 | Labeling nanostructure for signal amplification in immunoassays and immunoassays using the labeling nanostructure | 2021-06-11 |
| WO-2022098160-A1 | Gene-edited protein in which unnatural amino acid is site-specifically incorporated, and gene editing method using same | 2020-11-06 |
| CN-114235773-A | Raman imaging method for dynamically monitoring cell membrane repairing process | 2020-09-09 |
| WO-2021011927-A1 | Complement inhibitor dosing regimens | 2019-07-18 |
| US-2022280598-A1 | Complement inhibitor dosing regimens | 2019-07-18 |
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