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DBCO-PEG8-PFP ester
| Catalog Number | R01-0417 |
| Category | Cycloalkyne Dyes (DBCO) |
| Molecular Formula | C44H51F5N2O12 |
| Molecular Weight | 894.9 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
DBCO-PEG8-PFP ester is a PEG reagent comprising a DBCO group which can react with azides for copper-free Click Chemistry reactions. The PFP ester is an active ester which can be used to react with amine groups. PFP esters have been are stable compounds and are less susceptible to undergo hydrolysis. PEG8 linker increases the water solubility of a compound in aqueous media.
Chemical Information
Product Specification
Application
Computed Properties
| Purity | 98% |
| IUPAC Name | (2,3,4,5,6-pentafluorophenyl) 3-[2-[2-[2-[2-[2-[2-[2-[2-[[4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanoyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate |
| Canonical SMILES | C1C2=CC=CC=C2C#CC3=CC=CC=C3N1C(=O)CCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)OC4=C(C(=C(C(=C4F)F)F)F)F |
| InChI | InChI=1S/C44H51F5N2O12/c45-39-40(46)42(48)44(43(49)41(39)47)63-38(54)13-15-55-17-19-57-21-23-59-25-27-61-29-30-62-28-26-60-24-22-58-20-18-56-16-14-50-36(52)11-12-37(53)51-31-34-7-2-1-5-32(34)9-10-33-6-3-4-8-35(33)51/h1-8H,11-31H2,(H,50,52) |
| InChIKey | GLCCNJGHFRIUAJ-UHFFFAOYSA-N |
| Storage | -20 °C |
DBCO-PEG8-PFP ester, a versatile reagent prevalent in biomolecular research for bioconjugation and cross-linking applications, offers a myriad of uses. Here are four key applications of DBCO-PEG8-PFP ester:
Bioconjugation: Embracing DBCO-PEG8-PFP ester for biomolecular conjugation, researchers seamlessly link proteins and antibodies to diverse molecules or surfaces. Its distinct chemical composition enables precise and efficient attachment through click chemistry, ensuring steadfast and durable conjugation. This process is pivotal for crafting functionalized biomaterials and engineering targeted therapeutics with precision.
Drug Delivery Systems: Employing DBCO-PEG8-PFP ester propels the advancement of sophisticated drug delivery systems. Functioning as a crucial linker, the ester facilitates the coupling of therapeutic molecules to delivery vehicles like nanoparticles or liposomes. This mechanism guarantees accurate drug delivery to designated cells, heightening therapeutic efficacy while mitigating off-target effects, amplifying the impact of treatment strategies.
Surface Modification: DBCO-PEG8-PFP ester proves instrumental in surface modification endeavors, sculpting bioactive interfaces essential for diverse applications. Its utility extends to enhancing biosensor surfaces to elevate the sensitivity and specificity of detection assays, a vital component in the evolution of diagnostic tools and bioengineering apparatus.
Protein Cross-linking: Widely employed in protein-protein cross-linking studies, DBCO-PEG8-PFP ester stands as a cornerstone in unraveling intricate protein interactions and complex formations. By forging covalent bonds between specific amino acid residues, researchers stabilize transient interactions, unlocking invaluable insights into protein dynamics.
| XLogP3 | 2.8 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 17 |
| Rotatable Bond Count | 32 |
| Exact Mass | 894.33621588 g/mol |
| Monoisotopic Mass | 894.33621588 g/mol |
| Topological Polar Surface Area | 150Ų |
| Heavy Atom Count | 63 |
| Formal Charge | 0 |
| Complexity | 1360 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
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