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DBCO-PEG5-acid | 1870899-46-9
| Catelog Number | R01-0411 |
| Category | Cycloalkyne Dyes (DBCO) |
| Molecular Formula | C32H40N2O9 |
| Molecular Weight | 596.67 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| R01-0411 | -- | $-- |
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Product Introduction
DBCO-Amide-PEG5-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Chemical Information |
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|---|---|
| Synonyms | DBCO-NHCO-PEG4-acid; 3-[2-[2-[2-[2-[3-[[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]amino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid; DBCO-Amide-PEG5-acid |
| Purity | >98.0% |
| Shelf Life | ≥ 2 years |
| IUPAC Name | 3-[2-[2-[2-[2-[3-[[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]amino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid |
| Canonical SMILES | C1C2=CC=CC=C2C#CC3=CC=CC=C3N1C(=O)CCNC(=O)CCOCCOCCOCCOCCOCCC(=O)O |
| InChI | InChI=1S/C32H40N2O9/c35-30(12-15-39-17-19-41-21-23-43-24-22-42-20-18-40-16-13-32(37)38)33-14-11-31(36)34-25-28-7-2-1-5-26(28)9-10-27-6-3-4-8-29(27)34/h1-8H,11-25H2,(H,33,35)(H,37,38) |
| InChI Key | IBWIRDQMNBYUPH-UHFFFAOYSA-N |
| Solubility | 10 mm in DMSO |
| Appearance | Solid |
Product Specification |
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|---|---|
| Storage | Store at -5°C,keep in dry and avoid sunlight. |
Computed Properties | |
|---|---|
| XLogP3 | 0.8 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 9 |
| Rotatable Bond Count | 21 |
| Exact Mass | 596.27338086 g/mol |
| Monoisotopic Mass | 596.27338086 g/mol |
| Topological Polar Surface Area | 133Ų |
| Heavy Atom Count | 43 |
| Formal Charge | 0 |
| Complexity | 902 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| WO-2022155257-A1 | Systems, apparatuses, and methods for cellular therapeutics manufacture | 2021-01-12 |
| WO-2022125874-A2 | Methods for identification of exchangeable mhc binding peptides and methods of use thereof | 2020-12-11 |
| TW-202039008-A | Adcs with thiol multiplex linkers | 2018-12-21 |
| AU-2019403552-A1 | ADCs with thiol multiplex linkers | 2018-12-21 |
| CA-3122316-A1 | Adcs with thiol multiplex linkers | 2018-12-21 |
Applications of Fluorescent Probes & Dyes
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