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DBCO-PEG24-NHS ester
| Catalog Number | R01-0425 |
| Category | Cycloalkyne Dyes (DBCO) |
| Molecular Formula | C74H119N3O30 |
| Molecular Weight | 1530.8 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
DBCO-PEG24-NHS ester is a bifunctional reagent that features a dibenzocyclooctyne (DBCO) moiety and an N-hydroxysuccinimide (NHS) ester, connected by a polyethylene glycol (PEG) spacer. The DBCO group facilitates strain-promoted azide-alkyne cycloaddition (SPAAC) reactions, allowing for bioorthogonal conjugation with azide-functionalized biomolecules without the need for copper catalysis. The NHS ester component enables efficient amide bond formation with primary amines, making this reagent suitable for linking proteins, peptides, or other amine-containing substrates in bioconjugation and surface modification applications.
Chemical Information
Product Specification
Computed Properties
Patents
Chemical Information
| IUPAC Name | (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[[4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanoyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate |
| SMILES | C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCC(=O)N2CC3=CC=CC=C3C#CC4=CC=CC=C42 |
| InChI | InChI=1S/C74H119N3O30/c78-70(11-12-71(79)76-65-68-7-2-1-5-66(68)9-10-67-6-3-4-8-69(67)76)75-16-18-84-20-22-86-24-26-88-28-30-90-32-34-92-36-38-94-40-42-96-44-46-98-48-50-100-52-54-102-56-58-104-60-62-106-64-63-105-61-59-103-57-55-101-53-51-99-49-47-97-45-43-95-41-39-93-37-35-91-33-31-89-29-27-87-25-23-85-21-19-83-17-15-74(82)107-77-72(80)13-14-73(77)81/h1-8H,11-65H2,(H,75,78) |
| InChIKey | BGLMICCLAUJEEQ-UHFFFAOYSA-N |
Product Specification
| Storage | -20 °C |
Computed Properties
| XLogP3 | -2.5 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 30 |
| Rotatable Bond Count | 80 |
| Exact Mass | 1529.78783939 g/mol |
| Monoisotopic Mass | 1529.78783939 g/mol |
| Topological Polar Surface Area | 335Ų |
| Heavy Atom Count | 107 |
| Formal Charge | 0 |
| Complexity | 2160 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| US-2022096648-A1 | Antibody-drug conjugates comprising glp1 peptidomimetics and uses thereof | 2020-09-14 |
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