4-Methylumbelliferyl b-D-galactopyranoside-6-sulphate | 126938-14-5

Catalog Number	A18-0104
Category	Fluorescent Enzyme Substrates
Molecular Formula	C16H18O11S
Molecular Weight	418.37

Catalog Number	Size	Price	Quantity
A18-0104	--	$--

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Product Introduction

4-Methylumbelliferyl β-D-Galactopyranoside-6-sulfate (4-MU-Gal-6S) is a fluorogenic substrate for N-acetylgalactosamine-6-sulphatase (GALNS). 4-MU-Gal-6S is cleaved by GALNS to release the fluorescent moiety 4-MU. 4-MU fluorescence intensity increases as pH decreases. It has been used to detect Morquio disease type A, a lysosomal storage disorder in which GALNS is deficient.

Chemical Information
Related CAS	206443-06-3 (sodium salt)
Synonyms	4-MU β-D-galactopyranoside-6-sulfate; 4-Methylumbelliferyl Gal-6S; 4-MU-Gal-6S; 4-methyl-7-[(6-O-sulfo-β-D-galactopyranosyl)oxy]-2H-1-benzopyran-2-one
Purity	≥98%
IUPAC Name	[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methyl-2-oxochromen-7-yl)oxyoxan-2-yl]methyl hydrogen sulfate
Canonical SMILES	CC1=CC(=O)OC2=C1C=CC(=C2)OC3C(C(C(C(O3)COS(=O)(=O)O)O)O)O
InChI	InChI=1S/C16H18O11S/c1-7-4-12(17)26-10-5-8(2-3-9(7)10)25-16-15(20)14(19)13(18)11(27-16)6-24-28(21,22)23/h2-5,11,13-16,18-20H,6H2,1H3,(H,21,22,23)/t11-,13+,14+,15-,16-/m1/s1
InChI Key	PAMBMLAUEGWIPT-DZQJYWQESA-N
Solubility	Soluble in Water
Density	1.7±0.1 g/cm3
Appearance	White to Off-white Solid
Melting Point	196-200°C