Mag-fura-2 AM | CAS 130100-20-8

Catalog Number	A14-0070
Category	Calcium, Chloride and Other indicators
Molecular Formula	C30H30N2O19
Molecular Weight	722.57

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Product Introduction

Mag-fura-2 AM is a membrane-permeant, short-wavelength fluorescent indicator for intracellular magnesium. It can be loaded into cells via incubation, and hydrolyzed to mag-fura-2. Intracellular magnesium concentration can be measured by ratio of fluorescence intensity generated by mag-fura-2.

Chemical Information
Product Specification
Application

Synonyms	Mag-fura-2-AM; Mag-fura-2-acetoxymethyl ester; acetyloxymethyl 2-[5-[2-(acetyloxymethoxy)-2-oxoethoxy]-6-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]-1-benzofuran-2-yl]-1,3-oxazole-5-carboxylate
Canonical SMILES	CC(=O)OCOC(=O)CN(CC(=O)OCOC(=O)C)C1=C(C=C2C=C(OC2=C1)C3=NC=C(O3)C(=O)OCOC(=O)C)OCC(=O)OCOC(=O)C
InChI	InChI=1S/C30H30N2O19/c1-16(33)42-12-46-26(37)9-32(10-27(38)47-13-43-17(2)34)21-7-22-20(5-23(21)41-11-28(39)48-14-44-18(3)35)6-24(50-22)29-31-8-25(51-29)30(40)49-15-45-19(4)36/h5-8H,9-15H2,1-4H3
InChIKey	PCDUVTXECKTHBH-UHFFFAOYSA-N
Appearance	Solid Powder

Excitation	537
Emission	559 ±5

Mag-fura-2 AM, a cell-permeable ratiometric fluorescent indicator, serves as a versatile tool for measuring intracellular magnesium levels. Here are four key applications of Mag-fura-2 AM:

Cellular Magnesium Monitoring: Utilized extensively in diverse cell types, Mag-fura-2 AM enables real-time monitoring of intracellular magnesium concentrations. By tracking changes in magnesium levels dynamically, researchers gain invaluable insights into cellular physiology and metabolic processes. This application plays a pivotal role in unraveling the intricate interplay of magnesium in cellular functions and pathological conditions.

Neuroscience Research: In the realm of neuroscience, Mag-fura-2 AM plays a crucial role in investigating the impact of magnesium on neural activity and signaling events. This indicator facilitates the exploration of magnesium dynamics within neurons, shedding light on processes like synaptic transmission and neuronal plasticity. Such research efforts are vital for deciphering the nuanced molecular pathways underlying neurological disorders and the functionality of the brain.

Pharmacological Studies: Valued in pharmacological investigations, Mag-fura-2 AM serves as a key tool for probing the effects of pharmacological agents on intracellular magnesium balance. By leveraging this indicator, scientists can evaluate how diverse compounds modulate magnesium levels and associated cellular responses. This application aids in the identification of potential therapeutic candidates and enhances our comprehension of drug action mechanisms.

Cardiovascular Research: Within the domain of cardiovascular research, Mag-fura-2 AM is instrumental in scrutinizing magnesium’s influence on heart functionality and vascular health. Researchers leverage this indicator to measure magnesium levels in cardiac and vascular cells, contributing to studies on conditions such as hypertension, arrhythmias, and cardiovascular diseases. These insights are pivotal for advancing tailored therapeutic interventions aimed at mitigating cardiovascular disorders.