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IR-786 iodide | CAS 56289-67-9
| Catalog Number | A17-0098 |
| Category | Laser Dyes |
| Molecular Formula | C32H36ClIN2 |
| Molecular Weight | 611.00 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
IR-786 iodide is a remarkable biomedicine compound that has gained attention for its profound applications in combating various forms of cancer, prominently breast and lung cancer. Through its intricate mode of action, this exceptional compound ingeniously and selectively homes in on malignant cells, instigating programmed cell death and effectively restraining their uncontrolled proliferation.
Chemical Information
Application
| Synonyms | 2-[2-[2-Chloro-3-[2-(1,3-dihydro-1,3,3-trimethyl-2H-indol-2-ylidene)-ethylidene]-1-cyclohexen-1-yl]-ethenyl]-1,3,3-trimethyl-3H-indolium iodide |
| Canonical SMILES | CC1(C2=CC=CC=C2[N+](=C1C=CC3=C(C(=CC=C4C(C5=CC=CC=C5N4C)(C)C)CCC3)Cl)C)C.[I-] |
| InChI | InChI=1S/C32H36ClN2.HI/c1-31(2)24-14-7-9-16-26(24)34(5)28(31)20-18-22-12-11-13-23(30(22)33)19-21-29-32(3,4)25-15-8-10-17-27(25)35(29)6;/h7-10,14-21H,11-13H2,1-6H3;1H/q+1;/p-1 |
| InChIKey | UOKPQDRVXJDDCA-UHFFFAOYSA-M |
IR-786 iodide is a near-infrared fluorescent dye with a wide range of applications in bioscience and medical research. Here are some key applications of IR-786 iodide:
Biomedical Imaging: IR-786 iodide is extensively used in near-infrared (NIR) optical imaging to visualize biological tissues and structures. Its deep tissue penetration and low background fluorescence in biological samples make it ideal for in vivo imaging. This enables researchers to track the distribution and dynamics of cells and molecules in live organisms with high precision.
Cancer Diagnostics: The unique properties of IR-786 iodide make it a valuable tool in cancer diagnostics. It can be conjugated to targeting molecules, such as antibodies or peptides, to specifically label cancer cells. This targeted imaging approach facilitates the early detection and monitoring of tumors, improving diagnostic accuracy and enabling timely interventions.
Therapeutic Monitoring: IR-786 iodide can be used to monitor the biodistribution and efficacy of therapeutic agents in real-time. By labeling drugs or nanoparticles with this dye, researchers can track their delivery and accumulation in specific tissues. This application is crucial for optimizing drug delivery strategies and assessing therapeutic outcomes.
Photothermal Therapy: IR-786 iodide can be utilized in photothermal therapy (PTT) for cancer treatment. When exposed to NIR light, it generates heat, selectively destroying cancer cells without harming surrounding healthy tissue. This precise and minimally invasive approach holds great promise for enhancing the efficacy of cancer therapies and reducing side effects.
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