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IR 140 Perchlorate | CAS 53655-17-7
| Catalog Number | A17-0090 |
| Category | Laser Dyes |
| Molecular Formula | C39H34Cl2N3S2∙ClO4 |
| Molecular Weight | 779.19 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
IR 140 Perchlorate is a biomedical agent used for fluorescent imaging in biomedicine. It is commonly employed to visualize mitochondrial structure and function. This compound selectively stains mitochondria due to its lipophilic properties, aiding in the investigation of various mitochondrial diseases and drug effects on mitochondrial activity.
Chemical Information
Application
| Synonyms | 5-chloro-2-[2-[3-[(5-chloro-3-ethyl-2(3H)-benzothiazolylidene)ethylidene]-2-(diphenylamino)-1-cyclopenten-1-yl]ethenyl]-3-ethyl-benzothiazolium perchlorate; 5,5'-Dichloro-11-diphenylamino-3,3'-deithyl-10,12-ethylenethiatricarbocyanine perchlorate |
| Canonical SMILES | CCN1C2=C(C=CC(=C2)Cl)SC1=CC=C3CCC(=C3N(C4=CC=CC=C4)C5=CC=CC=C5)C=CC6=[N+](C7=C(S6)C=CC(=C7)Cl)CC.[O-]Cl(=O)(=O)=O |
| InChI | InChI=1S/C39H34Cl2N3S2.ClHO4/c1-3-42-33-25-29(40)19-21-35(33)45-37(42)23-17-27-15-16-28(18-24-38-43(4-2)34-26-30(41)20-22-36(34)46-38)39(27)44(31-11-7-5-8-12-31)32-13-9-6-10-14-32;2-1(3,4)5/h5-14,17-26H,3-4,15-16H2,1-2H3;(H,2,3,4,5)/q+1;/p-1 |
| InChIKey | UVLDECUUBLLYRG-UHFFFAOYSA-M |
IR 140 Perchlorate is a compound with varied applications, particularly in physiological and biochemical research. Here are some notable applications of IR 140 Perchlorate:
Fluorescent Labeling and Imaging: IR 140 Perchlorate is used as a fluorescent dye in biological imaging applications. It is particularly suitable for labeling proteins, nucleic acids, and other biomolecules due to its strong absorption and emission features. This allows researchers to visualize and track biological molecules and processes in live cells and tissues with high specificity and sensitivity.
Photodynamic Therapy: IR 140 Perchlorate can serve as a photosensitizer in photodynamic therapy (PDT), a treatment modality for various cancers and microbial infections. When activated by light of a specific wavelength, the dye produces reactive oxygen species that kill targeted cells. This approach allows localized treatment with minimal damage to surrounding healthy tissue and has shown promise in clinical applications.
Spectroscopic Studies: In spectroscopic applications, IR 140 Perchlorate is employed to study molecular interactions and dynamics. Its high quantum yield and distinctive spectral properties make it an excellent probe for fluorescence resonance energy transfer (FRET) experiments. Researchers can use it to monitor changes in molecular distances and conformational alterations in real-time.
Biochemical Assays: IR 140 Perchlorate is also valuable in various biochemical assays, where it is used to detect and quantify biological substances. For instance, it can be part of enzyme-linked immunosorbent assays (ELISAs) or other fluorescence-based detection methods. This enhances the sensitivity and accuracy of the assays, facilitating the identification and measurement of proteins, nucleic acids, and other analytes.
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