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Fura-PE3 AM | 172890-84-5
| Catalog Number | A14-0012 |
| Category | Calcium, Chloride Indictors and Other indicators |
| Molecular Formula | C55H63N5O29 |
| Molecular Weight | 1258.1 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A14-0012 | -- | $-- |
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Product Introduction
Fura-PE3 AM is a ratiometric indicator for measuring Ca2+. It is membrane-permeable and can be hydrolyzed by esterases to calcium indicator Fura-PE3. Compared to Fura-2, Fura-PE3 is similar in its properties but retained longer in cells.
Chemical Information |
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| Synonyms | Fura-2 Leakage Resistant; Fura-PE3 Acetoxymethyl ester; 4-[3-[3-[2-[[2-[5-[[(acetyloxy)methoxy]carbonyl]-2-oxazolyl]-6-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-5-benzofuranyl]oxy]ethoxy]-4-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]phenyl]-1-oxopropyl]-(acetyloxy)methyl ester-1-piperazineacetic acid |
| Purity | ≥95% |
| Canonical SMILES | CC(=O)OCOC(=O)CN1CCN(CC1)C(=O)CCC2=CC(=C(C=C2)N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C)OCCOC3=C(C=C4C(=C3)C=C(O4)C5=NC=C(O5)C(=O)OCOC(=O)C)N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C |
| InChI | InChI=1S/C55H63N5O29/c1-33(61)76-27-82-49(68)22-57-11-13-58(14-12-57)48(67)10-8-39-7-9-41(59(23-50(69)83-28-77-34(2)62)24-51(70)84-29-78-35(3)63)44(17-39)74-15-16-75-45-18-40-19-46(54-56-21-47(89-54)55(73)87-32-81-38(6)66)88-43(40)20-42(45)60(25-52(71)85-30-79-36(4)64)26-53(72)86-31-80-37(5)65/h7,9,17-21H,8,10-16,22-32H2,1-6H3 |
| InChI Key | CGAZNAYDEAJZHQ-UHFFFAOYSA-N |
| Appearance | Solid Powder |
- Product Specification
- Application
| Excitation | 364 nm (no Ca2+), 335 nm (Ca2+-bound) |
| Emission | 508 nm (no Ca2+), 495 nm (Ca2+-bound) |
| Storage | Store at -20°C |
Fura-PE3 AM, a widely used fluorescent calcium indicator dye, plays a significant role in biological and medical research. Here are four key applications of Fura-PE3 AM, portrayed with a high degree of perplexity and burstiness:
Intracellular Calcium Imaging: Leveraging the unique properties of Fura-PE3 AM, researchers can delve into the intricate realm of intracellular calcium dynamics within live cells. By intricately loading cells with this dye, scientists embark on a journey to track real-time fluctuations in calcium levels, a pivotal aspect of cellular signaling and intercellular communication. This technique stands as a cornerstone in unraveling the mysteries of processes like muscle contraction, neurotransmitter release, and immune cell activation, offering a profound glimpse into the intricate dance of cellular activities.
Neuroscience Research: A beacon of light in the vast expanse of neuroscience, Fura-PE3 AM illuminates the path to understanding neuronal activities through the precise measurement of calcium dynamics in neurons. The symphony of calcium signaling orchestrates critical functions in synaptic transmission, plasticity, and the overall orchestration of brain function. Through the lens of Fura-PE3 AM, neuroscientists are able to visually capture and quantify transient calcium events, unearthing the hidden realms of neuronal networks and unraveling the enigmas of brain disorders.
Cardiac Function Studies: In the heart of cardiac research, Fura-PE3 AM emerges as a vital tool for exploring the intricate dance of calcium regulation within cardiac cells. The pulsating rhythm of calcium ions orchestrates the symphony of cardiac muscle contraction and relaxation. By meticulously scrutinizing calcium fluxes using Fura-PE3 AM, researchers gain a window into cardiac health, delving into the realm of arrhythmias and evaluating the impact of pharmacological interventions on heart function, shedding light on the beating heart of medical research.
Pharmacological Screening: Fura-PE3 AM serves as a beacon guiding researchers in the screening of drug effects on cellular calcium signaling. By meticulously evaluating the fluctuations in calcium levels post-drug exposure, scientists unveil the efficacy and potential side effects of novel compounds. This application stands as a pivotal cornerstone in the saga of drug discovery, heralding a new era of therapeutic innovation across diverse disease landscapes.
Applications of Fluorescent Probes & Dyes
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