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FBBBE
| Catalog Number | A16-0013 |
| Category | Other Cell Fluorescent Probes |
| Molecular Formula | C46H46B2O9 |
| Molecular Weight | 764.5 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A16-0013 | -- | -- |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
FBBBE is a derivative of fluorescein for imaging the production of intracellular hydrogen peroxide (H2O2).
Chemical Information
Product Specification
Application
| Synonyms | 3',6'-bis((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)-3H-spiro[isobenzofuran-1,9'-xanthen]-3-one; Fluorescein bis (benzyl boronic ester) |
| Purity | ≥95% |
| Canonical SMILES | B1(OC(C(O1)(C)C)(C)C)C2=CC=C(C=C2)COC3=CC4=C(C=C3)C5(C6=C(O4)C=C(C=C6)OCC7=CC=C(C=C7)B8OC(C(O8)(C)C)(C)C)C9=CC=CC=C9C(=O)O5 |
| InChI | InChI=1S/C46H46B2O9/c1-42(2)43(3,4)55-47(54-42)31-17-13-29(14-18-31)27-50-33-21-23-37-39(25-33)52-40-26-34(22-24-38(40)46(37)36-12-10-9-11-35(36)41(49)53-46)51-28-30-15-19-32(20-16-30)48-56-44(5,6)45(7,8)57-48/h9-26H,27-28H2,1-8H3 |
| InChIKey | UKXLQKOGCSYSOD-UHFFFAOYSA-N |
| Appearance | Solid Powder |
| Excitation | 480 nm |
| Emission | 512 nm |
| Storage | Store at -20°C |
FBBBE, a derivative of fluorescein, is a robust molecular probe used extensively in the medical and biochemical fields for detecting and imaging intracellular hydrogen peroxide (H2O2). This compound is engineered to selectively respond to H2O2, facilitating the study of oxidative stress within biological systems. The presence of H2O2, a reactive oxygen species, serves as an indicator of oxidative stress, which is implicated in numerous physiological and pathological processes, including aging, cancer, and neurodegenerative diseases. FBBBE’s high sensitivity and specificity enable researchers to visualize real-time changes in H2O2 levels, thus providing invaluable insights into cellular redox states under various conditions.
One of the key applications of FBBBE is in cancer research. As cancer cells often exhibit altered redox balance with increased levels of reactive oxygen species, including H2O2, FBBBE serves as a critical tool for understanding these pathological conditions. Researchers utilize FBBBE to monitor H2O2 production, helping to elucidate the role of oxidative stress in cancer progression, metastasis, and response to therapies. This aids in the development of new therapeutic strategies aimed at manipulating oxidative stress to inhibit cancerous growth.
In addition to cancer studies, FBBBE is instrumental in neuroscience research to investigate neurodegenerative diseases such as Alzheimer’s and Parkinson’s. These conditions are characterized by oxidative damage in neuronal cells. By employing FBBBE, scientists can assess the levels of H2O2 in brain tissues, thereby gaining insights into the mechanisms of neuronal damage and death. This understanding contributes to the development of antioxidant-based therapeutic approaches aimed at mitigating neuronal loss and cognitive decline in affected individuals.
FBBBE is also crucial in cardiovascular research. The imbalance of reactive oxygen species, including H2O2, plays a significant role in the pathogenesis of cardiovascular diseases, such as atherosclerosis and hypertension. Researchers use FBBBE to visualize and quantify H2O2 levels in vascular tissues. This information aids in identifying the contribution of oxidative stress to vascular dysfunction and helps in formulating strategies to bolster vascular health through antioxidant therapies.
Furthermore, FBBBE finds use in the study of aging processes. Oxidative stress is a fundamental contributor to the aging process and age-related disorders. By monitoring H2O2 levels in cells and tissues using FBBBE, researchers are able to explore the correlation between oxidative stress and aging. Insights gained from these studies may lead to innovative anti-aging interventions and enhance our understanding of the molecular mechanisms underlying aging.
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