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Sulforhodamine 101 | 60311-02-6
| Catalog Number | A16-0014 |
| Category | Other Cell Fluorescent Probes |
| Molecular Formula | C31H30N2O7S2 |
| Molecular Weight | 606.7 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A16-0014 | -- | $-- |
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Product Introduction
Sulforhodamine 101 is a red fluorescent dye that is used as a selective marker for astrocytes and an activity-dependent probe for monitoring regulated exocytosis.
Chemical Information |
|
|---|---|
| Synonyms | 9-(2,4-disulfophenyl)-2,3,6,7,12,13,16,17-octahydro-1H,5H,11H,15H-xantheno[2,3,4-ij:5,6,7-i'j']diquinolizin-18-ium, inner salt; SR 101; Sulforhodamine 640; Texas Red, Sulforhodamine 101 Acid Chloride |
| Purity | ≥95% |
| IUPAC Name | 2-(3-oxa-23-aza-9-azoniaheptacyclo[17.7.1.15,9.02,17.04,15.023,27.013,28]octacosa-1(27),2(17),4,9(28),13,15,18-heptaen-16-yl)-5-sulfobenzenesulfonate |
| Canonical SMILES | C1CC2=C3C(=C4C(=C2)C(=C5C=C6CCC[N+]7=C6C(=C5O4)CCC7)C8=C(C=C(C=C8)S(=O)(=O)O)S(=O)(=O)[O-])CCCN3C1 |
| InChI | InChI=1S/C31H30N2O7S2/c34-41(35,36)20-9-10-21(26(17-20)42(37,38)39)27-24-15-18-5-1-11-32-13-3-7-22(28(18)32)30(24)40-31-23-8-4-14-33-12-2-6-19(29(23)33)16-25(27)31/h9-10,15-17H,1-8,11-14H2,(H-,34,35,36,37,38,39) |
| InChI Key | COIVODZMVVUETJ-UHFFFAOYSA-N |
| Appearance | Green to Dark Green Solid |
- Product Specification
- Application
| Excitation | 586 nm |
| Emission | 605 nm |
| Storage | Store at -20°C |
Sulforhodamine 101, a vibrant red fluorescent dye, finds widespread use in diverse scientific research applications. Explore four key applications of Sulforhodamine 101:
Neuroimaging: Delving into neuroimaging studies, Sulforhodamine 101 emerges as a pivotal tool for labeling astrocytes - the glial cells in our brain. By intricately staining these astrocytes, researchers unveil their intricate architecture and monitor their dynamic activity within live tissue. This sharpens our comprehension of astrocyte functions and their intricate interplay within neural circuits, illuminating the roots of brain vitality and health.
Cell Viability Assays: In the realm of cell biology, Sulforhodamine 101 steps into the spotlight, serving as a linchpin in cytotoxicity and cell proliferation assays. By binding to cellular proteins, it furnishes a tangible measure of cell density and viability. This application proves invaluable in scrutinizing the impacts of drugs, chemicals, or genetic alterations on cell survival and proliferation, enriching our grasp of cellular dynamics.
Histology: Stepping into the world of histology, Sulforhodamine 101 emerges as a vivid stain for illuminating cellular structures within fixed tissue samples. Its high-contrast luminous fluorescence transforms detailed tissue examinations under a microscope, unveiling the intricacies of tissue morphology and pathology across diverse organ systems with unparalleled clarity.
Live Cell Imaging: Gazing at live-cell imaging, Sulforhodamine 101 shines as a beacon for tracking and observing cells in real-time. Its robust fluorescence empowers the monitoring of dynamic processes within cells - from intracellular transport to organelle interactions. This critical application unveils the secrets of cellular behavior and responses in a vibrant living context, offering unprecedented insights into the inner workings of cellular life.
Computed Properties | |
|---|---|
| XLogP3 | 2.2 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 2 |
| Exact Mass | 606.14944365 g/mol |
| Monoisotopic Mass | 606.14944365 g/mol |
| Topological Polar Surface Area | 144Ų |
| Heavy Atom Count | 42 |
| Formal Charge | 0 |
| Complexity | 1450 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 22734511 | 2012-09-11 | Investigating ligand-receptor interactions at bilayer surface using electronic absorption spectroscopy and fluorescence resonance energy transfer | Langmuir : the ACS journal of surfaces and colloids |
| 22279011 | 2012-04-01 | Intracellular Na+ concentration influences short-term plasticity of glutamate transporter-mediated currents in neocortical astrocytes | Glia |
| 22383644 | 2012-03-01 | In vivo labeling of cortical astrocytes with sulforhodamine 101 (SR101) | Cold Spring Harbor protocols |
| 22231909 | 2012-02-13 | Live monitoring of cargo release from peptide-based hybrid nanocapsules induced by enzyme cleavage | Macromolecular rapid communications |
| 22509398 | 2012-01-01 | Specific in vivo staining of astrocytes in the whole brain after intravenous injection of sulforhodamine dyes | PloS one |
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-114479838-A | A kind of light-harvesting system based on pillar aromatic hydrocarbon and its preparation method and application | 2022-01-20 |
| US-11376570-B1 | Method of forming copper oxide-on-copper nanomaterial catalyst mesh | 2021-07-21 |
| US-2023022846-A1 | Methods For Determining A Photodetector Gain Correction Factor For Optical Signals In A Flow Cytometer | 2021-07-13 |
| EP-4113106-A1 | Antimicrobial surface coating formation, detection, quantification and reactivation systems and methods | 2021-07-02 |
| WO-2022269534-A1 | Use of single cell elisa starting from deparaffinzed cells for the detection of molecules of interest | 2021-06-23 |
Applications of Fluorescent Probes & Dyes
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