EGTA acetoxymethyl ester | 99590-86-0

EGTA acetoxymethyl ester, a cell-permeable calcium chelator, is widely utilized in biochemical and cell biology research. Here are four key applications of EGTA acetoxymethyl ester:

Calcium Signaling Studies: Within the realm of cellular research, EGTA-AM plays a pivotal role in precise control of intracellular calcium levels across diverse cell types. By chelating calcium ions, researchers delve into the intricate interplay of calcium in signaling pathways, cellular processes, and physiological responses. This exploration sheds light on how calcium ions intricately contribute to vital functions, such as muscle contraction, neurotransmission, and various cellular activities.

Neurobiology: In the domain of neurobiological inquiry, EGTA-AM emerges as a crucial tool for dissecting the influence of calcium on neuronal function and intercellular communication. By modulating calcium concentrations, scientists embark on a journey to unravel the underlying mechanisms of synaptic transmission, plasticity, and neurodegeneration. This endeavor holds promise in uncovering potential therapeutic targets for debilitating neurological conditions like Alzheimer’s and Parkinson’s, enhancing our understanding of the intricate workings of the brain.

Cardiac Physiology: Researchers venture into the realm of cardiac physiology with EGTA-AM as their ally, probing into the significance of calcium in orchestrating cardiac muscle contraction and heart function. Through meticulous control of calcium levels, they scrutinize the intricate mechanisms governing cardiac myocyte contraction and relaxation. This profound understanding serves as a cornerstone for the development of novel treatments aimed at addressing cardiac afflictions such as arrhythmias and heart failure, paving the way for enhanced cardiovascular health.

Cell Viability Assays: EGTA-AM takes center stage in cell viability assessments and cytotoxicity studies, providing invaluable insights into the effects of various compounds on cellular survival. By chelating calcium, researchers unlock the secrets of how alterations in calcium homeostasis impact cell viability and apoptosis. This knowledge serves as a crucial asset in drug discovery endeavors and toxicology studies, enabling the evaluation of potential side effects of emerging medications and contributing to the advancement of pharmaceutical science.