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Cryptocyanine | CAS 4727-50-8
| Catalog Number | A17-0082 |
| Category | Laser Dyes |
| Molecular Formula | C25H25IN2 |
| Molecular Weight | 480.38 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Near-infrared fluorescent dye for optical imaging and photothermal therapy. Exhibits high absorption and biocompatibility.
Chemical Information
Product Specification
Application
Computed Properties
Literatures
| Synonyms | 1-ethyl-4-[(3-(1-ethyl-4(1H)-quinolinylidene)-1-propenyl]-quinolinium iodide; 1,1'-diethyl-4,4'-carbocyanine iodide |
| IUPAC Name | (4E)-1-ethyl-4-[(E)-3-(1-ethylquinolin-1-ium-4-yl)prop-2-enylidene]quinoline;iodide |
| Canonical SMILES | CCN1C=CC(=CC=CC2=CC=[N+](C3=CC=CC=C23)CC)C4=CC=CC=C41.[I-] |
| InChI | InChI=1S/C25H25N2.HI/c1-3-26-18-16-20(22-12-5-7-14-24(22)26)10-9-11-21-17-19-27(4-2)25-15-8-6-13-23(21)25;/h5-19H,3-4H2,1-2H3;1H/q+1;/p-1 |
| InChIKey | CEJANLKHJMMNQB-UHFFFAOYSA-M |
| Signal | Danger |
| GHSHazardStatements | H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral] H315 (97.44%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (97.44%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] |
| Precautionary Statement Codes | P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.) |
Cryptocyanine, a versatile synthetic dye, finds application across scientific research and medical diagnostics. Here are four key applications of Cryptocyanine:
Fluorescent Imaging: Cryptocyanine serves as a prominent fluorescent dye in biological imaging, showcasing its ability to emit fluorescence under specific light wavelengths. This unique feature makes it a preferred choice for labeling and visualizing cellular structures and biomolecules in fluorescence microscopy. This crucial application aids in analyzing cellular behavior, tracking molecular interactions, and diagnosing diseases with precision and depth.
Photodynamic Therapy: Embracing innovative medical techniques, Cryptocyanine plays a pivotal role in photodynamic therapy (PDT), harnessing light activation to trigger the production of reactive oxygen species targeting and eliminating cancer cells. By focusing on specific tissues, Cryptocyanine elevates the precision and efficacy of cancer treatments, minimizing harm to surrounding healthy tissues. This approach offers a refined, targeted, and minimally invasive therapeutic avenue for combating cancer.
Cell Viability Assay: In the realm of cell analysis, Cryptocyanine emerges as a critical component in cell viability assays, facilitating the evaluation of cell health and proliferation. By integrating the dye into cells, researchers can quantify fluorescence intensity directly correlating with the number of viable cells. This indispensable application aids in drug screening, cytotoxicity assessment, and analyzing the impact of diverse treatments on cell populations, thereby contributing to enhanced precision and reliability in cellular studies.
NIR Fluorescence Imaging: Leveraging its near-infrared (NIR) fluorescence properties, Cryptocyanine finds utilization in in vivo imaging for tracking biological processes in live animals. NIR imaging offers enhanced tissue penetration and reduced background autofluorescence, enhancing image clarity and precision in visualizing complex biological processes. This application proves particularly valuable for investigating pharmacokinetics, biodistribution of drugs, and monitoring tumor progression in preclinical models, providing valuable insights with heightened accuracy and depth.
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 4 |
| Exact Mass | 480.10625 g/mol |
| Monoisotopic Mass | 480.10625 g/mol |
| Topological Polar Surface Area | 7.1Ų |
| Heavy Atom Count | 28 |
| Formal Charge | 0 |
| Complexity | 527 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 2 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 2 |
| Compound Is Canonicalized | Yes |
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 17480068 | 2007-05-31 | Tracking ultrafast excited-state bond-twisting motion in solution close to the Franck-Condon point | The journal of physical chemistry. B |
| 9333 | 1976-11-01 | Association of inflammatory bowel disease and large vascular lesions | Gastroenterology |
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