Coumarin 7 | 27425-55-4

Product Introduction

Coumarin 7 is an extensively employed synthetic compound within the biomedical sector. It stands as an indispensable fluorescent probe instrumental in scrutinizing multifarious biological mechanisms encompassing the domains of pharmaceutical conveyance, enzymatic operations, and cellular visualization. Furthermore, its profound antioxidant and anti-inflammatory attributes have been recognized, thus unveiling promising therapeutic capabilities towards maladies like cancer and neurodegenerative ailments.

Chemical Information
Synonyms	3-(1H-benzimidazol-2-yl)-7-(diethylamino)-2H-1-benzopyran-2-one; Coumarin 535; 3-(2-Benzimidazolyl)-7-(diethylamino)coumarin
Purity	>98.0%(T)(HPLC)
IUPAC Name	3-(1H-benzimidazol-2-yl)-7-(diethylamino)chromen-2-one
Canonical SMILES	CCN(CC)C1=CC2=C(C=C1)C=C(C(=O)O2)C3=NC4=CC=CC=C4N3
InChI	InChI=1S/C20H19N3O2/c1-3-23(4-2)14-10-9-13-11-15(20(24)25-18(13)12-14)19-21-16-7-5-6-8-17(16)22-19/h5-12H,3-4H2,1-2H3,(H,21,22)
InChI Key	GOLORTLGFDVFDW-UHFFFAOYSA-N
Appearance	White to Light yellow powder to crystal
Melting Point	242 °C

Product Specification
Storage	Store under inert gas
Application	Coumarins are used as fluorescent dyes and also as laser dyes. Fluorescent dyes not only absorb light; they also emit light to produce very bright colors. They are used to dye textile fibers, plastics, inks, and to make pigments for paints and lacquers. As a disperse dye, 40 Yellow is used to dye polyester fibers.
Signal	Warning
GHS Hazard Statements	H315 (21.91%): Causes skin irritation [Warning Skin corrosion/irritation] H317 (78.09%): May cause an allergic skin reaction [Warning Sensitization, Skin] H319 (21.91%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (42.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
Precautionary Statement Codes	P261, P264, P264+P265, P271, P272, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P333+P313, P337+P317, P362+P364, P403+P233, P405, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.)

Computed Properties
XLogP3	4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Exact Mass	333.147726857 g/mol
Monoisotopic Mass	333.147726857 g/mol
Topological Polar Surface Area	58.2Ų
Heavy Atom Count	25
Formal Charge	0
Complexity	531
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Literatures

PMID	Publication Date	Title	Journal
21992548	2012-02-01	Solanum tuberosum lectin-conjugated PLGA nanoparticles for nose-to-brain delivery: in vivo and in vitro evaluations	Journal of drug targeting
22382327	2012-01-01	Functional characterization of allelic variants of polymorphic human cytochrome P450 2A6 (CYP2A6*5, *7, *8, *18, *19, and *35)	Biological & pharmaceutical bulletin
21244437	2011-10-01	Inhibition of cytochrome P450 2A participating in coumarin 7-hydroxylation in pig liver microsomes	Journal of veterinary pharmacology and therapeutics
20836976	2010-09-01	Polymeric nanoparticle encapsulation of a naturally occurring plant scopoletin and its effects on human melanoma cell A375	Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
20729216	2010-08-27	The bell-shaped curve for peroxynitrite-mediated oxidation and nitration of NO/O2-* is alive and well	The Journal of biological chemistry

Patents

Publication Number	Title	Priority Date
CN-115236936-A	A femtosecond laser curing cross-linked polyamic acid photoresist and its preparation method, use method and application	2022-09-22
CN-115236936-B	A femtosecond laser curing crosslinked polyamic acid photoresist and its preparation method, use method and application	2022-09-22
CN-114415471-B	A kind of siloxane-based two-photon photoresist and its preparation method, use method and application	2022-03-01
EP-4112600-A1	Vinyl thianthrenium compound, process for its preparation and its use for transferring a vinyl group	2021-07-03
WO-2023280638-A1	Vinyl thianthrenium compound, process for its preparation and its use for transferring a vinyl group	2021-07-03