MitoMark Green I | CAS 201860-17-5

Catalog Number	A16-0005
Category	Mitochondrial Fluorescent Probes
Molecular Formula	C34H28Cl5N3O
Molecular Weight	671.87

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Product Introduction

MitoMark Green I is a green fluorescent mitochondrial stain.

Chemical Information
Product Specification
Application

Synonyms	2-[3-[5,6-Dichloro-1,3-bis[[4-(chloromethyl)phenyl]methyl]-1,3-dihydro-2H-benzimidazol-2-ylidene]-1-propen-1-yl]-3-methylbenzoxazolium chloride; Mitotracker Green
Canonical SMILES	C[N+]1=C(OC2=CC=CC=C21)C=CC=C3N(C4=CC(=C(C=C4N3CC5=CC=C(C=C5)CCl)Cl)Cl)CC6=CC=C(C=C6)CCl.[Cl-]
InChI	InChI=1S/C34H28Cl4N3O.ClH/c1-39-29-5-2-3-6-32(29)42-34(39)8-4-7-33-40(21-25-13-9-23(19-35)10-14-25)30-17-27(37)28(38)18-31(30)41(33)22-26-15-11-24(20-36)12-16-26;/h2-18H,19-22H2,1H3;1H/q+1;/p-1
InChIKey	RUVJFMSQTCEAAB-UHFFFAOYSA-M

Storage

Store at -20°C

MitoMark Green I is a fluorescent dye specifically designed for staining mitochondria in live cells, making it an invaluable tool in various bioscience applications. Here are some key applications of MitoMark Green I:

Live Cell Imaging: MitoMark Green I is widely used for live cell imaging to visualize and study mitochondrial dynamics in real-time. Researchers can track mitochondrial movement, fusion, and fission events within living cells. This facilitates understanding of mitochondrial physiology and dysfunction in various diseases.

Apoptosis Studies: MitoMark Green I can be employed in apoptosis studies to assess mitochondrial membrane potential, a key indicator of early apoptosis. By measuring the changes in fluorescence intensity, scientists can determine the onset of cell death and evaluate the efficacy of anti-apoptotic drugs. This is pivotal in cancer research and in developing therapies for apoptosis-related disorders.

Drug Screening: In the context of drug discovery, MitoMark Green I is utilized to screen compounds for their effects on mitochondrial function. By monitoring changes in mitochondrial morphology and activity, researchers can identify potential drug candidates that either restore or disrupt mitochondrial function. This aids in the development of therapies targeting mitochondrial-related diseases.

Mitochondrial Toxicity Assays: MitoMark Green I is essential for conducting mitochondrial toxicity assays to evaluate the safety of new drugs and chemicals. By staining mitochondria and observing the impact of test compounds, scientists can identify mitochondrial perturbations and potential toxicity. This ensures the safe development and use of pharmaceuticals and other products.