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Tetramethylrhodamine methyl ester perchlorate | 115532-50-8
| Catalog Number | A16-0053 |
| Category | Mitochondrial Fluorescent Probes |
| Molecular Formula | C25H25N2O3·ClO4 |
| Molecular Weight | 500.9 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A16-0053 | -- | $-- |
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Product Introduction
Tetramethylrhodamine methyl ester (TMRM) perchlorate is a cell-permeant red fluorescent probe commonly used to monitor membrane potential of mitochondria using live cell fluorescence microscopy and flow cytometry. TMRM is a lipophilic cation accumulated by mitochondria and exhibits a red shift in the emission of 575 nm. However, when the membrane is depolarized, as in apoptosis, TMRM is not accumulated in the mitochondria. Thus, the strength of the fluorescence signal in mitochondria is used to assess cell viability.
Chemical Information |
|
|---|---|
| Synonyms | TMRM Perchlorate; TMR methyl ester perchlorate; 3,6-bis(dimethylamino)-9-[2-(methoxycarbonyl)phenyl]-xanthylium perchlorate |
| Purity | ≥98% |
| IUPAC Name | [6-(dimethylamino)-9-(2-methoxycarbonylphenyl)xanthen-3-ylidene]-dimethylazanium;perchlorate |
| Canonical SMILES | CN(C)C1=CC2=C(C=C1)C(=C3C=CC(=[N+](C)C)C=C3O2)C4=CC=CC=C4C(=O)OC.[O-]Cl(=O)(=O)=O |
| InChI | InChI=1S/C25H25N2O3.ClHO4/c1-26(2)16-10-12-20-22(14-16)30-23-15-17(27(3)4)11-13-21(23)24(20)18-8-6-7-9-19(18)25(28)29-5;2-1(3,4)5/h6-15H,1-5H3;(H,2,3,4,5)/q+1;/p-1 |
| InChI Key | PFYWPQMAWCYNGW-UHFFFAOYSA-M |
| Appearance | Solid Powder |
- Product Specification
| Excitation | 515, 555 nm |
| Emission | 575 nm |
| Storage | Store at -20°C |
| Signal | Warning |
| GHS Hazard Statements | H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] |
| Precautionary Statement Codes | P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.) |
Computed Properties | |
|---|---|
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 4 |
| Exact Mass | 500.1350288 g/mol |
| Monoisotopic Mass | 500.1350288 g/mol |
| Topological Polar Surface Area | 116Ų |
| Heavy Atom Count | 35 |
| Formal Charge | 0 |
| Complexity | 868 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 2 |
| Compound Is Canonicalized | Yes |
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-114480254-A | In vitro surrogate model of hepatotoxicity constructed by HepaRG and HepG2 and its construction method and application | 2022-02-25 |
| WO-2022251654-A1 | Mitoneet ligands for use in protection from tissue ischemic reperfusion injury | 2021-05-28 |
| KR-20220159831-A | A mitocondrial-targeting nucleopeptide and a pharmaceutical composition for preventing or treating cancer comprising the same | 2021-05-26 |
| KR-20220146154-A | Composition for preventing or treating mitochondrial dysfunction―diseases containing isoquinoline derivative compound as an active ingredient | 2021-04-23 |
| WO-2022225108-A1 | Composition for preventing or treating diseases caused by mitochondrial dysfunction, containing isoquinoline derivative compound as active ingredient | 2021-04-23 |
Applications of Fluorescent Probes & Dyes
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