4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one

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4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one

4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one | 25392-41-0

Catelog Number A16-0155
Category Other Cell Fluorescent Probes
Molecular Formula C10H7ClO3
Molecular Weight 210.61
Catalog Number Size Price Quantity
A16-0155 -- $--
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Product Introduction

4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one is a thiol-reactive, cell-permeant fluorescent probe that easily passes through cell membranes.

Chemical Information
Synonyms CellHunt Blue CMHC
IUPAC Name 4-(chloromethyl)-7-hydroxychromen-2-one
Canonical SMILES C1=CC2=C(C=C1O)OC(=O)C=C2CCl
InChI InChI=1S/C10H7ClO3/c11-5-6-3-10(13)14-9-4-7(12)1-2-8(6)9/h1-4,12H,5H2
InChI Key TXSLBPGPBNGHRW-UHFFFAOYSA-N
Appearance Solid Powder

Product Specification
Excitation 348
Emission 423

Computed Properties
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 1
Exact Mass 210.0083718 g/mol
Monoisotopic Mass 210.0083718 g/mol
Topological Polar Surface Area 46.5Ų
Heavy Atom Count 14
Formal Charge 0
Complexity 275
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

Literatures

PMIDPublication DateTitleJournal
22614805 2012-08-01 TGF-β of lung cancer microenvironment upregulates B7H1 and GITRL expression in dendritic cells and is associated with regulatory T cell generation Oncology reports
21559411 2011-04-29 Monitoring the systemic human memory B cell compartment of melanoma patients for anti-tumor IgG antibodies PloS one
20580555 2010-08-01 Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II Bioorganic & medicinal chemistry letters
19932027 2010-01-01 alpha-Glucosidase inhibitory antihyperglycemic activity of substituted chromenone derivatives Bioorganic & medicinal chemistry
18251491 2008-02-27 Coumarin as attractive casein kinase 2 (CK2) inhibitor scaffold: an integrate approach to elucidate the putative binding motif and explain structure-activity relationships Journal of medicinal chemistry

Patents

Publication NumberTitlePriority Date
CN-114805432-A Novel photocatalytic cleavable carboxylic acid protecting group and preparation method of amino acid derivatives thereof 2022-03-03
WO-2022260135-A1 Method for producing fluorescent probe library using solid-phase extraction and method of measuring enzyme activity using same 2021-06-09
CN-112240879-A Fluorescent nanomaterial sensors and related methods 2019-07-17
DE-102020208745-A1 FLUORESCENT NANOMATERIAL SENSORS AND RELATED PROCEDURES 2019-07-17
US-2021015410-A1 Fluorescent nanomaterial sensors and related methods 2019-07-17

Applications of Fluorescent Probes & Dyes

Laser Dye

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