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2-Aminopurine Dihydrochloride | CAS 1428126-74-2
| Catalog Number | A19-0002 |
| Category | DNA Stains |
| Molecular Formula | C5H5N5·2HCl |
| Molecular Weight | 208.1 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A19-0002 | -- | -- |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
2-Aminopurine is a fluorescent analog of guanosine and adenosine, and can be used as a DNA probe for structural dynamics and charge transfer.
Chemical Information
Product Specification
Application
Computed Properties
| Related CAS | 452-06-2 (free base) |
| Synonyms | 9H-purin-2-amine, dihydrochloride; 2-AP |
| Purity | ≥98% |
| IUPAC Name | 7H-purin-2-amine;dihydrochloride |
| Canonical SMILES | C1=C2C(=NC(=N1)N)N=CN2.Cl.Cl |
| InChI | InChI=1S/C5H5N5.2ClH/c6-5-7-1-3-4(10-5)9-2-8-3;;/h1-2H,(H3,6,7,8,9,10);2*1H |
| InChIKey | ZMYNIVFDDGHSJU-UHFFFAOYSA-N |
| Appearance | Off-white to Pale Yellow Solid |
| Storage | Store at -20°C |
2-Aminopurine Dihydrochloride, a versatile chemical compound extensively utilized in molecular biology and biochemistry research, offers a plethora of applications. Here are four key applications of 2-Aminopurine Dihydrochloride:
Mutagenesis Studies: Serving as a potent mutagen in genetic investigations, 2-Aminopurine Dihydrochloride plays a pivotal role in inducing base-pair substitutions during DNA replication. By integrating into DNA in lieu of adenine or guanine, it triggers mispairing, leading to mutations. This mechanism aids researchers in unraveling mutation pathways, exploring gene functionality, and dissecting gene regulation intricacies.
Fluorescent Tagging: Positioned as a luminous counterpart to adenine, 2-Aminopurine Dihydrochloride is instrumental in scrutinizing nucleic acid interactions and dynamics. This compound enables real-time monitoring of DNA and RNA structural alterations through fluorescence spectroscopy. Such visualization techniques offer invaluable insights into molecular processes like DNA replication, repair, and transcription, augmenting our understanding of genetic mechanisms.
Protein-DNA Interactions: Employed to investigate protein-DNA couplings, 2-Aminopurine Dihydrochloride’s fluorescence is extinguished upon direct protein contact. By monitoring fluorescence modifications, researchers can assess binding strengths and kinetics of DNA-binding proteins. This data is imperative for deciphering transcriptional control mechanisms and comprehending DNA repair processes in depth.
Structural Biology: Within the domain of structural biology, 2-Aminopurine Dihydrochloride facilitates the exploration of nucleic acid structures and dynamics. Its integration into DNA permits the analysis of helical stability and identification of structural transitions. This capability proves invaluable for studying DNA-protein interactions and evaluating the impact of mutations on DNA stability, enriching our insights into molecular interactions within biological systems.
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 0 |
| Exact Mass | 207.0078506 g/mol |
| Monoisotopic Mass | 207.0078506 g/mol |
| Topological Polar Surface Area | 80.5Ų |
| Heavy Atom Count | 12 |
| Formal Charge | 0 |
| Complexity | 127 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 3 |
| Compound Is Canonicalized | Yes |
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