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9-Amino-6-chloro-2-methoxyacridine | 3548-09-2
| Catalog Number | A19-0004 |
| Category | DNA Stains |
| Molecular Formula | C14H11ClN2O |
| Molecular Weight | 258.7 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A19-0004 | -- | $-- |
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Product Introduction
9-Amino-6-chloro-2-methoxyacridine (ACMA) is a cell-permeable fluorescent probe for labeling DNA with selectivity for poly(dA-dT) sequences. ACMA fluorescence is quenched when a pH gradient is established, a property that has been utilized in animal- and plant-based studies. It also inhibits acetylcholinesterase with a Ki value of 49 nM.
Chemical Information |
|
|---|---|
| Synonyms | ACMA; 6-chloro-2-methoxy-9-acridinamine |
| Purity | ≥98% |
| IUPAC Name | 6-chloro-2-methoxyacridin-9-amine |
| Canonical SMILES | COC1=CC2=C(C3=C(C=C(C=C3)Cl)N=C2C=C1)N |
| InChI | InChI=1S/C14H11ClN2O/c1-18-9-3-5-12-11(7-9)14(16)10-4-2-8(15)6-13(10)17-12/h2-7H,1H3,(H2,16,17) |
| InChI Key | IHHSSHCBRVYGJX-UHFFFAOYSA-N |
| Appearance | Solid Powder |
- Product Specification
| Excitation | 411 nm |
| Emission | 475 nm |
| Storage | Store at -20°C |
| Signal | Warning |
| GHS Hazard Statements | H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] H351 (100%): Suspected of causing cancer [Warning Carcinogenicity] |
| Precautionary Statement Codes | P203, P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.) |
Computed Properties | |
|---|---|
| XLogP3 | 3.4 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 1 |
| Exact Mass | 258.0559907 g/mol |
| Monoisotopic Mass | 258.0559907 g/mol |
| Topological Polar Surface Area | 48.1Ų |
| Heavy Atom Count | 18 |
| Formal Charge | 0 |
| Complexity | 302 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 23123248 | 2013-03-25 | Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors | Chemico-biological interactions |
| 22362183 | 2012-04-07 | The mode of binding ACMA-DNA relies on the base-pair nature | Organic & biomolecular chemistry |
| 21971327 | 2011-11-21 | ACMA (9-amino-6-chloro-2-methoxy acridine) forms three complexes in the presence of DNA | Physical chemistry chemical physics : PCCP |
| 21926988 | 2011-09-18 | Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase | Nature cell biology |
| 21619897 | 2011-08-01 | Acridine derivatives as anti-BVDV agents | Antiviral research |
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-114333062-B | Person Re-identification Model Training Method Based on Heterogeneous Dual Network and Feature Consistency | 2021-12-31 |
| KR-20220169639-A | Rapid molecular diagnosis system for on-site diagnosis for new corona 19 virus quarantine | 2021-06-21 |
| CN-113499452-A | A kind of poly-N-vinyl caprolactam nanogel loaded with gold and manganese dioxide nanoparticles and its preparation and application | 2021-06-11 |
| CN-113499452-B | A kind of poly N-vinylcaprolactam nanogel loaded with gold and manganese dioxide nanoparticles and its preparation and application | 2021-06-11 |
| US-2022403450-A1 | Systems and methods for sequencing nucleotides using two optical channels | 2021-06-03 |
Applications of Fluorescent Probes & Dyes
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