Z-DEVD-AFC | 1135416-11-3

Catelog Number	A18-0043
Category	Fluorescent Enzyme Substrates
Molecular Formula	C36H38F3N5O14
Molecular Weight	821.7

Catalog Number	Size	Price	Quantity
A18-0043	--	$--

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Product Introduction

Z-DEVD-AFC is a fluorogenic substrate for caspase-3. It is cleaved by caspase-3 to release the fluorescent moiety 7-amino-7-trifluoromethylcoumarin (AFC), which can be used to quantify caspase-3 activity.

Chemical Information
Synonyms	Caspase-3 Fluorogenic Substrate IV; (5S,8S,11S,14S)-8-(2-carboxyethyl)-5-(carboxymethyl)-11-isopropyl-3,6,9,12-tetraoxo-14-((2-oxo-4-(trifluoromethyl)-2H-chromen-7-yl)carbamoyl)-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oic acid
Purity	≥95%
IUPAC Name	(4S)-5-[[(2S)-1-[[(2S)-3-carboxy-1-oxo-1-[[2-oxo-4-(trifluoromethyl)chromen-7-yl]amino]propan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-[[(2S)-3-carboxy-2-(phenylmethoxycarbonylamino)propanoyl]amino]-5-oxopentanoic acid
Canonical SMILES	CC(C)C(C(=O)NC(CC(=O)O)C(=O)NC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F)NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)OCC3=CC=CC=C3
InChI	InChI=1S/C36H38F3N5O14/c1-17(2)30(34(55)42-23(14-27(47)48)32(53)40-19-8-9-20-21(36(37,38)39)13-29(51)58-25(20)12-19)44-31(52)22(10-11-26(45)46)41-33(54)24(15-28(49)50)43-35(56)57-16-18-6-4-3-5-7-18/h3-9,12-13,17,22-24,30H,10-11,14-16H2,1-2H3,(H,40,53)(H,41,54)(H,42,55)(H,43,56)(H,44,52)(H,45,46)(H,47,48)(H,49,50)/t22-,23-,24-,30-/m0/s1
InChI Key	JEPURZRNABGOCW-CQUCHYGKSA-N

Product Specification
Storage	Store at -20°C

Computed Properties
XLogP3	1.1
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	17
Rotatable Bond Count	20
Exact Mass	821.23673539 g/mol
Monoisotopic Mass	821.23673539 g/mol
Topological Polar Surface Area	293Å²
Heavy Atom Count	58
Formal Charge	0
Complexity	1600
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Literatures

PMID	Publication Date	Title	Journal
11598139	2001-12-14	Characterization of fortilin, a novel antiapoptotic protein	The Journal of biological chemistry
9696873	1998-09-01	Caspase activation and specific cleavage of substrates after coxsackievirus B3-induced cytopathic effect in HeLa cells	Journal of virology
9185777	1997-06-01	Processing/activation of CPP32-like proteases is involved in transforming growth factor beta1-induced apoptosis in rat hepatocytes	Hepatology (Baltimore, Md.)

Patents

Publication Number	Title	Priority Date
US-2004260094-A1	Quinoline derivatives as caspase-3 inhibitor, preparation for producing the same and pharmaceutical composition comprising the same	2002-04-30
US-7009053-B2	Quinoline derivatives as caspase-3 inhibitor, preparation for producing the same and pharmaceutical composition comprising the same	2002-04-30
US-2001010814-A1	Adenoviral vector encoding pro-apoptotic bax gene and uses thereof	1998-08-24

Applications of Fluorescent Probes & Dyes

Laser Dye

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Z-DEVD-AFC | 1135416-11-3

Product Introduction

Chemical Information

Product Specification

Computed Properties

Literatures

Patents