Z-DEVD-AFC

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Z-DEVD-AFC

Z-DEVD-AFC | 1135416-11-3

Catalog Number A18-0043
Category Fluorescent Enzyme Substrates
Molecular Formula C36H38F3N5O14
Molecular Weight 821.7
Catalog Number Size Price Quantity
A18-0043 -- $--

Product Introduction

Z-DEVD-AFC is a fluorogenic substrate for caspase-3. It is cleaved by caspase-3 to release the fluorescent moiety 7-amino-7-trifluoromethylcoumarin (AFC), which can be used to quantify caspase-3 activity.

Chemical Information

Synonyms Caspase-3 Fluorogenic Substrate IV; (5S,8S,11S,14S)-8-(2-carboxyethyl)-5-(carboxymethyl)-11-isopropyl-3,6,9,12-tetraoxo-14-((2-oxo-4-(trifluoromethyl)-2H-chromen-7-yl)carbamoyl)-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oic acid
Purity ≥95%
IUPAC Name (4S)-5-[[(2S)-1-[[(2S)-3-carboxy-1-oxo-1-[[2-oxo-4-(trifluoromethyl)chromen-7-yl]amino]propan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-[[(2S)-3-carboxy-2-(phenylmethoxycarbonylamino)propanoyl]amino]-5-oxopentanoic acid
Canonical SMILES CC(C)C(C(=O)NC(CC(=O)O)C(=O)NC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F)NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)OCC3=CC=CC=C3
InChI InChI=1S/C36H38F3N5O14/c1-17(2)30(34(55)42-23(14-27(47)48)32(53)40-19-8-9-20-21(36(37,38)39)13-29(51)58-25(20)12-19)44-31(52)22(10-11-26(45)46)41-33(54)24(15-28(49)50)43-35(56)57-16-18-6-4-3-5-7-18/h3-9,12-13,17,22-24,30H,10-11,14-16H2,1-2H3,(H,40,53)(H,41,54)(H,42,55)(H,43,56)(H,44,52)(H,45,46)(H,47,48)(H,49,50)/t22-,23-,24-,30-/m0/s1
InChI Key JEPURZRNABGOCW-CQUCHYGKSA-N
  • Product Specification
Storage Store at -20°C

Computed Properties

XLogP3 1.1
Hydrogen Bond Donor Count 8
Hydrogen Bond Acceptor Count 17
Rotatable Bond Count 20
Exact Mass 821.23673539 g/mol
Monoisotopic Mass 821.23673539 g/mol
Topological Polar Surface Area 293Ų
Heavy Atom Count 58
Formal Charge 0
Complexity 1600
Isotope Atom Count 0
Defined Atom Stereocenter Count 4
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

Literatures

PMIDPublication DateTitleJournal
11598139 2001-12-14 Characterization of fortilin, a novel antiapoptotic protein The Journal of biological chemistry
9696873 1998-09-01 Caspase activation and specific cleavage of substrates after coxsackievirus B3-induced cytopathic effect in HeLa cells Journal of virology
9185777 1997-06-01 Processing/activation of CPP32-like proteases is involved in transforming growth factor beta1-induced apoptosis in rat hepatocytes Hepatology (Baltimore, Md.)

Patents

Publication NumberTitlePriority Date
US-2004260094-A1 Quinoline derivatives as caspase-3 inhibitor, preparation for producing the same and pharmaceutical composition comprising the same 2002-04-30
US-7009053-B2 Quinoline derivatives as caspase-3 inhibitor, preparation for producing the same and pharmaceutical composition comprising the same 2002-04-30
US-2001010814-A1 Adenoviral vector encoding pro-apoptotic bax gene and uses thereof 1998-08-24
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