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Pyronin Y | CAS 92-32-0
| Catalog Number | A19-0042 |
| Category | DNA Stains |
| Molecular Formula | C17H19ClN2O |
| Molecular Weight | 302.8 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Pyronin Y is a fluorescent probe that stains double stranded RNA in living or fixed cells as well as in tissues. It has been shown to accumulate in the mitochondria of viable cells.
Chemical Information
Product Specification
Application
Computed Properties
Patents
| Synonyms | Pyronine Y; 3,6-bis(dimethylamino)-xanthylium, monochloride |
| IUPAC Name | [6-(dimethylamino)xanthen-3-ylidene]-dimethylazanium;chloride |
| Canonical SMILES | CN(C)C1=CC2=C(C=C1)C=C3C=CC(=[N+](C)C)C=C3O2.[Cl-] |
| InChI | InChI=1S/C17H19N2O.ClH/c1-18(2)14-7-5-12-9-13-6-8-15(19(3)4)11-17(13)20-16(12)10-14;/h5-11H,1-4H3;1H/q+1;/p-1 |
| InChIKey | INCIMLINXXICKS-UHFFFAOYSA-M |
| Solubility | Soluble in DMSO. |
| Appearance | Solid Powder |
| Excitation | 540-550 nm |
| Emission | 560-580 nm |
| Storage | Store at -20°C |
| Signal | Warning |
| GHSHazardStatements | H341 (100%): Suspected of causing genetic defects [Warning Germ cell mutagenicity] |
| Precautionary Statement Codes | P203, P281, P318, P405, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.) |
Pyronin Y is a cationic dye commonly used in various scientific and clinical applications. Here are some key applications of Pyronin Y:
Nucleic Acid Staining: Pyronin Y is extensively used for staining RNA in cells and tissues. It selectively binds to RNA, allowing researchers to visualize and quantify RNA content under a microscope. This is particularly useful in histology and cytology for studying cell cycle dynamics and differentiation processes.
Flow Cytometry: In flow cytometry, Pyronin Y is employed to distinguish between quiescent and actively cycling cells. When used in combination with other DNA-binding dyes, it enables the identification of cells in different phases of the cell cycle. This information is critical for cancer research and cell cycle studies.
Bacterial Viability Testing: Pyronin Y can be utilized to assess bacterial viability by differentiating between live and dead cells. Live cells retain Pyronin Y, appearing red, whereas dead cells do not, making it possible to quickly evaluate the efficacy of antimicrobial treatments. This application is valuable in microbiological diagnostics and antibiotic testing.
Transcriptional Activity Measurement: Pyronin Y is also used to measure transcriptional activity in living cells. By staining RNA-rich regions, it reflects the levels of transcriptional activity, providing insights into gene expression patterns. This is particularly helpful in understanding cellular responses to different environmental conditions and treatments.
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 1 |
| Exact Mass | 302.1185909 g/mol |
| Monoisotopic Mass | 302.1185909 g/mol |
| Topological Polar Surface Area | 15.5Ų |
| Heavy Atom Count | 21 |
| Formal Charge | 0 |
| Complexity | 480 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 2 |
| Compound Is Canonicalized | Yes |
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-114716357-A | A kind of alkyl substituted chalcogenide and preparation method thereof | 2022-05-19 |
| CN-217809433-U | An optical system of a PCR fluorescence detector and a PCR fluorescence detector | 2022-04-22 |
| CN-114894586-A | A kind of compound type super-living S staining solution with reduced interference | 2022-03-18 |
| CN-114216885-B | A kind of fluorescence detection method of sulfide ion and its application | 2021-11-18 |
| US-11512342-B1 | Compositions and methods for detecting pyrophosphate products of enzyme reactions using pyridylazoaniline dyes | 2021-11-01 |
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