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MeoSuc-Ala-Ala-Pro-Val-AMC | 72252-90-5
| Catalog Number | A18-0015 |
| Category | Fluorescent Enzyme Substrates |
| Molecular Formula | C31H41N5O9 |
| Molecular Weight | 627.7 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A18-0015 | -- | $-- |
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Product Introduction
MeOSuc-AAPV-AMC is a fluorogenic substrate for human leukocyte and porcine pancreatic elastase. The methoxy succinyl (MeO-Suc) peptide AAPV is hydrolyzed by these elastases but not by cathepsin G. The addition of 7-amino-4-methylcoumarin (AMC) generates a peptide of low fluorescence (excitation: 355-380 nm; emission 440-460 nm) that demonstrates a linear increase in fluorescence intensity in the presence of elastase.
Chemical Information |
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|---|---|
| Synonyms | MeOSuc-AAPV-AMC;I 1270; Methoxy Succinyl-Ala-Ala-Pro-Val-AMC; N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-L-prolyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-valinamide |
| Purity | ≥95% by HPLC |
| IUPAC Name | methyl 4-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-3-methyl-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoate |
| Canonical SMILES | CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)C(C(C)C)NC(=O)C3CCCN3C(=O)C(C)NC(=O)C(C)NC(=O)CCC(=O)OC |
| InChI | InChI=1S/C31H41N5O9/c1-16(2)27(30(42)34-20-9-10-21-17(3)14-26(39)45-23(21)15-20)35-29(41)22-8-7-13-36(22)31(43)19(5)33-28(40)18(4)32-24(37)11-12-25(38)44-6/h9-10,14-16,18-19,22,27H,7-8,11-13H2,1-6H3,(H,32,37)(H,33,40)(H,34,42)(H,35,41)/t18-,19-,22-,27-/m0/s1 |
| InChI Key | CMEUDEVBFFPSEI-NFHWZJRKSA-N |
| Solubility | Soluble in DMSO, DMF |
| Appearance | White to Off-white Powder |
- Product Specification
| Excitation | 355-380 nm |
| Emission | 440-460 nm |
| Storage | Store at -20°C |
Computed Properties | |
|---|---|
| XLogP3 | 1 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 9 |
| Rotatable Bond Count | 13 |
| Exact Mass | 627.29042790 g/mol |
| Monoisotopic Mass | 627.29042790 g/mol |
| Topological Polar Surface Area | 189Ų |
| Heavy Atom Count | 45 |
| Formal Charge | 0 |
| Complexity | 1200 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 4 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| EP-3929209-A1 | Vasopressin-2 receptor antagonist peptides and uses thereof | 2020-06-24 |
| WO-2021102176-A2 | Polypeptide inhibitors of neutrophil elastase activity and uses thereof | 2019-11-21 |
| JP-2023502508-A | Polypeptide inhibitors of neutrophil elastase activity and uses thereof | 2019-11-21 |
| US-2022372111-A1 | Polypeptide inhibitors of neutrophil elastase activity and uses thereof | 2019-11-21 |
| WO-2020150751-A2 | Devices and methods for tissue and cell staining (ii) | 2019-01-15 |
Applications of Fluorescent Probes & Dyes
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